The brain as a target organ of gonadal steroids

A. R. Genazzani, M. Gastaldi, B. Bidzinska, N. Mercuri, A. D. Genazzani, R. E. Nappi, A. Segre, F. Petraglia

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Gonadal steroids have many effects in the central nervous system. Through a feedback mechanism, they influence the synthesis and release of hypothalamic gonadotropin-releasing hormone (GnRH) and/or pituitary gonadotropic hormones (luteinizing hormone, LH, and follicle stimulating hormone, FSH). endogenous opioid peptides (EOPs) represent one of the key factors modulating the activity of sex steroids on the hypothalamus-pituitary-gonadal (HPG) axis. In particular, these peptides control the secretion of LH by inhibiting the activity of the hypothalamic neurons which produce GnRH. The EOP effect is dependent on the steroid hormone milieu, as shown by different responses to naloxone administration, both in animals and in humans. For the naloxone-induced increase in LH secretion to occur, relatively high levels of sex steroids are required. In humans, LH release is absent before sexual maturation. In fertile women, naloxone administration increases LH levels in the luteal phase but not in the follicular phase. In the postmenopausal period, naloxone has no effect on LH release; estrogen/progestin therapy does restore the LH response.

Original languageEnglish
Pages (from-to)385-390
Number of pages6
JournalPsychoneuroendocrinology
Volume17
Issue number4
DOIs
Publication statusPublished - 1992

Fingerprint

Naloxone
Steroids
Opioid Peptides
Brain
Gonadotropin-Releasing Hormone
Pituitary Hormone-Releasing Hormones
Postmenopause
Sexual Maturation
Follicular Phase
Pituitary Hormones
Luteal Phase
Follicle Stimulating Hormone
Progestins
Luteinizing Hormone
Hypothalamus
Estrogens
Central Nervous System
Hormones
Neurons
Peptides

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

Genazzani, A. R., Gastaldi, M., Bidzinska, B., Mercuri, N., Genazzani, A. D., Nappi, R. E., ... Petraglia, F. (1992). The brain as a target organ of gonadal steroids. Psychoneuroendocrinology, 17(4), 385-390. https://doi.org/10.1016/0306-4530(92)90043-7

The brain as a target organ of gonadal steroids. / Genazzani, A. R.; Gastaldi, M.; Bidzinska, B.; Mercuri, N.; Genazzani, A. D.; Nappi, R. E.; Segre, A.; Petraglia, F.

In: Psychoneuroendocrinology, Vol. 17, No. 4, 1992, p. 385-390.

Research output: Contribution to journalArticle

Genazzani, AR, Gastaldi, M, Bidzinska, B, Mercuri, N, Genazzani, AD, Nappi, RE, Segre, A & Petraglia, F 1992, 'The brain as a target organ of gonadal steroids', Psychoneuroendocrinology, vol. 17, no. 4, pp. 385-390. https://doi.org/10.1016/0306-4530(92)90043-7
Genazzani AR, Gastaldi M, Bidzinska B, Mercuri N, Genazzani AD, Nappi RE et al. The brain as a target organ of gonadal steroids. Psychoneuroendocrinology. 1992;17(4):385-390. https://doi.org/10.1016/0306-4530(92)90043-7
Genazzani, A. R. ; Gastaldi, M. ; Bidzinska, B. ; Mercuri, N. ; Genazzani, A. D. ; Nappi, R. E. ; Segre, A. ; Petraglia, F. / The brain as a target organ of gonadal steroids. In: Psychoneuroendocrinology. 1992 ; Vol. 17, No. 4. pp. 385-390.
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