The brain of the elderly between normality and pathology: Techniques and technologies for the evaluation

M. Catan, A. Cherubini, R. Tarducci, M. C. Polidori, M. Piccirilli, G. Gobbi, G. P. Pelliccioli, U. Senin, P. Mecocci

Research output: Contribution to journalArticlepeer-review


Increasing attention has been devoted in recent years to elderly subjects suffering from a cognitive impairment which is greater than that expected with normal aging but still insufficient to fulfil the diagnostic criteria for dementia. Mild cognitive decline (MCI) is the term most widely used to define these subjects from the clinical point of view. Among the different approaches that have been undertaken to recognize MCI and to characterize its progression or stability, interesting results are emerging from neuroimaging studies, both morphological (computerized tomography: CT, magnetic resonance imaging: MRI) and functional (positron emission tomography: PET, single photon emission computed tomography: SPECT, proton magnetic resonance spectroscopy: 1H-MRS). Using 1H-MRS we demonstrated that MCI subjects have a white matter biochemical pattern similar to those of early Alzheimer disease (AD) patients, but different from healthy elderly subjects. These results provide additional evidence that MCI does not belong to the normal aging of the brain.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalArchives of Gerontology and Geriatrics
Issue numberSUPPL.
Publication statusPublished - 2001


  • H-MRS
  • Alzheimer's disease
  • Mild cognitive impairment
  • Myo-inositol

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)


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