The two main roles of the immune system are protection from infections and maintenance of immunological tolerance (avoiding "self-aggression"). Impairment of these functions results in the onset of immunodeficiency and/or autoimmunity. Here are summarized the mechanisms of immunological tolerance and the main characteristics of two paradigmatic monogenic diseases due to the loss of a tolerance mechanisms. Finally, three examples are reported regarding how the knowledge acquired on immune tolerance paved the way for the definition of new therapeutic interventions in the context of transplantation and genetic diseases with immune dysregulation.
|Translated title of the contribution||The breaking of tolerance in autoimmune diseases and its induction in transplantation medicine|
|Number of pages||2|
|Publication status||Published - 2014|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health