TY - JOUR
T1 - The broad landscape of follicular lymphoma
T2 - Part II
AU - Fratoni, Stefano
AU - Zanelli, Magda
AU - Zizzo, Maurizio
AU - Sanguedolce, Francesca
AU - Aimola, Valentina
AU - Cerrone, Giulia
AU - Ricci, Linda
AU - Filosa, Alessandra
AU - Martino, Giovanni
AU - Fara, Antonella Maria
AU - Annessi, Valerio
AU - Soriano, Alessandra
AU - Ascani, Stefano
N1 - Copyright © 2020 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.
PY - 2020/6
Y1 - 2020/6
N2 - Follicular lymphoma is a neoplasm derived from follicle center B cells, typically both centrocytes and centroblasts, in variable proportions according to the lymphoma grading. The pattern of growth may be entirely follicular, follicular and diffuse and rarely completely diffuse. It represents the second most common non-Hodgkin lymphoma, after diffuse large B-cell lymphoma and it is the most common low-grade mature B-cell lymphoma in Western countries. In the majority of cases, follicular lymphoma is a nodal tumor, occurring in adults and is frequently associated with the translocation t(14;18)(q32;q21)/IGH-BCL2. However, in recent years the spectrum of follicular lymphoma has expanded and small subsets of follicular lymphoma, which differ from common follicular lymphoma, have been identified and included in the current 2017 WHO classification. The aim of our review is to describe the broad spectrum of follicular lymphoma, pointing out that the identification of distinct clinicopathological variants of follicular lymphoma is relevant for the patient outcomes and treatment.
AB - Follicular lymphoma is a neoplasm derived from follicle center B cells, typically both centrocytes and centroblasts, in variable proportions according to the lymphoma grading. The pattern of growth may be entirely follicular, follicular and diffuse and rarely completely diffuse. It represents the second most common non-Hodgkin lymphoma, after diffuse large B-cell lymphoma and it is the most common low-grade mature B-cell lymphoma in Western countries. In the majority of cases, follicular lymphoma is a nodal tumor, occurring in adults and is frequently associated with the translocation t(14;18)(q32;q21)/IGH-BCL2. However, in recent years the spectrum of follicular lymphoma has expanded and small subsets of follicular lymphoma, which differ from common follicular lymphoma, have been identified and included in the current 2017 WHO classification. The aim of our review is to describe the broad spectrum of follicular lymphoma, pointing out that the identification of distinct clinicopathological variants of follicular lymphoma is relevant for the patient outcomes and treatment.
U2 - 10.32074/1591-951X-6-20
DO - 10.32074/1591-951X-6-20
M3 - Review article
C2 - 32202535
VL - 112
SP - 79
EP - 92
JO - Pathologica
JF - Pathologica
SN - 0031-2983
IS - 2
ER -