TY - JOUR
T1 - The burden of breast cancer in Italy
T2 - Mastectomies and quadrantectomies performed between 2001 and 2008 based on nationwide hospital discharge records
AU - Piscitelli, Prisco
AU - Barba, Maddalena
AU - Crespi, Massimo
AU - Di Maio, Massimo
AU - Santoriello, Antonio
AU - D'Aiuto, Massiliamo
AU - Fucito, Alfredo
AU - Losco, Arturo
AU - Pentimalli, Francesca
AU - Maranta, Pasquale
AU - Chitano, Giovanna
AU - Argentiero, Alberto
AU - Neglia, Cosimo
AU - Distante, Alessandro
AU - Di Tanna, Gian Luca
AU - Brandi, Maria Luisa
AU - Mazza, Alfredo
AU - Marino, Ignazio R.
AU - Giordano, Antonio
PY - 2012
Y1 - 2012
N2 - Background: Where population coverage is limited, the exclusive use of Cancer Registries might limit ascertainment of incident cancer cases. We explored the potentials of Nationwide hospital discharge records (NHDRs) to capture incident breast cancer cases in Italy. Methods. We analyzed NHDRs for mastectomies and quadrantectomies performed between 2001 and 2008. The average annual percentage change (AAPC) and related 95% Confidence Interval (CI) in the actual number of mastectomies and quadrantectomies performed during the study period were computed for the full sample and for subgroups defined by age, surgical procedure, macro-area and singular Region. Re-admissions of the same patients were separately presented. Results: The overall number of mastectomies decreased, with an AAPC of -2.1% (-2.3 -1.8). This result was largely driven by the values observed for women in the 45 to 64 and 65 to 74 age subgroups (-3.0%, -3.4 -3.6 and -3.3%, -3.8 -2.8, respectively). We observed no significant reduction in mastectomies for women in the remaining age groups. Quadrantectomies showed an overall +4.7 AAPC (95%CI:4.5-4.9), with no substantial differences by age. Analyses by geographical area showed a remarkable decrease in mastectomies, with inter-regional discrepancies possibly depending upon variability in mammography screening coverage and adherence. Quadrantectomies significantly increased, with Southern Regions presenting the highest average rates. Data on repeat admissions within a year revealed a total number of 46,610 major breast surgeries between 2001 and 2008, with an overall +3.2% AAPC (95%CI:2.8-3.6). Conclusions: In Italy, NHDRs might represent a valuable supplemental data source to integrate Cancer Registries in cancer surveillance.
AB - Background: Where population coverage is limited, the exclusive use of Cancer Registries might limit ascertainment of incident cancer cases. We explored the potentials of Nationwide hospital discharge records (NHDRs) to capture incident breast cancer cases in Italy. Methods. We analyzed NHDRs for mastectomies and quadrantectomies performed between 2001 and 2008. The average annual percentage change (AAPC) and related 95% Confidence Interval (CI) in the actual number of mastectomies and quadrantectomies performed during the study period were computed for the full sample and for subgroups defined by age, surgical procedure, macro-area and singular Region. Re-admissions of the same patients were separately presented. Results: The overall number of mastectomies decreased, with an AAPC of -2.1% (-2.3 -1.8). This result was largely driven by the values observed for women in the 45 to 64 and 65 to 74 age subgroups (-3.0%, -3.4 -3.6 and -3.3%, -3.8 -2.8, respectively). We observed no significant reduction in mastectomies for women in the remaining age groups. Quadrantectomies showed an overall +4.7 AAPC (95%CI:4.5-4.9), with no substantial differences by age. Analyses by geographical area showed a remarkable decrease in mastectomies, with inter-regional discrepancies possibly depending upon variability in mammography screening coverage and adherence. Quadrantectomies significantly increased, with Southern Regions presenting the highest average rates. Data on repeat admissions within a year revealed a total number of 46,610 major breast surgeries between 2001 and 2008, with an overall +3.2% AAPC (95%CI:2.8-3.6). Conclusions: In Italy, NHDRs might represent a valuable supplemental data source to integrate Cancer Registries in cancer surveillance.
KW - Breast cancer
KW - Cancer surveillance
KW - Hospital discharge records
KW - Mastectomies
KW - Quadrantectomies
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U2 - 10.1186/1756-9966-31-96
DO - 10.1186/1756-9966-31-96
M3 - Article
C2 - 23168067
AN - SCOPUS:84869154954
VL - 31
JO - Journal of Experimental and Clinical Cancer Research
JF - Journal of Experimental and Clinical Cancer Research
SN - 0392-9078
IS - 1
M1 - 96
ER -