The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure

Mitja Lainscak, Lea Majc Hodoscek, Hans Dirk Düngen, Mathias Rauchhaus, Wolfram Doehner, Stefan D. Anker, Stephan Von Haehling

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

OBJECTIVES: Like chronic heart failure, chronic obstructive pulmonary disease (COPD) is an enormous public health problem in industrialized countries. Our aim was to determine the prevalence and clinical impact of COPD among patients hospitalized for heart failure in a community hospital serving a population of 125,000 people. METHODS: Between 2001 and 2003 a total of 638 patients (73 ± 10 years, 48% men, 74% NYHA class III) were identified with a discharge diagnosis of heart failure. Medical charts were reviewed and vital status was obtained from a Central Population Registry. RESULTS: COPD was diagnosed in 106 (17%) patients whose age was similar to those without COPD (73 ± 9 vs. 73 ± 11 years, P = 0.35). Patients with COPD were more often males (65% vs. 45%, P <0.001). There were no differences in arterial hypertension, atrial fibrillation, diabetes mellitus and most laboratory markers except hemoglobin (141 ± 20 vs. 132 ± 20 g/l, P <0.001) and uric acid (453 ± 136 vs. 414 ± 139 mmol/l, P = 0.013). At discharge, patients with COPD were less likely to receive beta-blockers (12% vs. 28%, odds ratio 0.35, 95% CI0.19-0.64). During follow-up, patients with COPD had higher mortality (73% vs. 60%, P = 0.016, hazard ratio 1.48, 95% CI 1.15-1.90). Kaplan-Meier (log-rank test, P = 0.002) and Cox proportional hazard analysis, adjusted for age, sex, hemoglobin, uric acid, and treatment with beta-blockers and furosemide (hazard ratio 1.38, 95% CI1.04-1.83, P = 0.024) demonstrated the prognostic importance of COPD. CONCLUSIONS: COPD is frequent among hospitalized patients with heart failure. Beta-blockers are largely underused, which is probably a major reason for the higher mortality observed in patients with concomitant chronic heart failure and COPD.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalWiener Klinische Wochenschrift
Volume121
Issue number9-10
DOIs
Publication statusPublished - 2009

Fingerprint

Chronic Obstructive Pulmonary Disease
Heart Failure
Uric Acid
Hemoglobins
Mortality
Community Hospital
Furosemide
Developed Countries
Atrial Fibrillation
Population
Registries
Diabetes Mellitus
Public Health
Biomarkers
Odds Ratio
Hypertension

Keywords

  • Chronic heart failure
  • Chronic obstructive pulmonary disease
  • Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lainscak, M., Hodoscek, L. M., Düngen, H. D., Rauchhaus, M., Doehner, W., Anker, S. D., & Von Haehling, S. (2009). The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure. Wiener Klinische Wochenschrift, 121(9-10), 309-313. https://doi.org/10.1007/s00508-009-1185-8

The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure. / Lainscak, Mitja; Hodoscek, Lea Majc; Düngen, Hans Dirk; Rauchhaus, Mathias; Doehner, Wolfram; Anker, Stefan D.; Von Haehling, Stephan.

In: Wiener Klinische Wochenschrift, Vol. 121, No. 9-10, 2009, p. 309-313.

Research output: Contribution to journalArticle

Lainscak, M, Hodoscek, LM, Düngen, HD, Rauchhaus, M, Doehner, W, Anker, SD & Von Haehling, S 2009, 'The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure', Wiener Klinische Wochenschrift, vol. 121, no. 9-10, pp. 309-313. https://doi.org/10.1007/s00508-009-1185-8
Lainscak, Mitja ; Hodoscek, Lea Majc ; Düngen, Hans Dirk ; Rauchhaus, Mathias ; Doehner, Wolfram ; Anker, Stefan D. ; Von Haehling, Stephan. / The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure. In: Wiener Klinische Wochenschrift. 2009 ; Vol. 121, No. 9-10. pp. 309-313.
@article{0bec41583be345f2b013108a666ce6e6,
title = "The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure",
abstract = "OBJECTIVES: Like chronic heart failure, chronic obstructive pulmonary disease (COPD) is an enormous public health problem in industrialized countries. Our aim was to determine the prevalence and clinical impact of COPD among patients hospitalized for heart failure in a community hospital serving a population of 125,000 people. METHODS: Between 2001 and 2003 a total of 638 patients (73 ± 10 years, 48{\%} men, 74{\%} NYHA class III) were identified with a discharge diagnosis of heart failure. Medical charts were reviewed and vital status was obtained from a Central Population Registry. RESULTS: COPD was diagnosed in 106 (17{\%}) patients whose age was similar to those without COPD (73 ± 9 vs. 73 ± 11 years, P = 0.35). Patients with COPD were more often males (65{\%} vs. 45{\%}, P <0.001). There were no differences in arterial hypertension, atrial fibrillation, diabetes mellitus and most laboratory markers except hemoglobin (141 ± 20 vs. 132 ± 20 g/l, P <0.001) and uric acid (453 ± 136 vs. 414 ± 139 mmol/l, P = 0.013). At discharge, patients with COPD were less likely to receive beta-blockers (12{\%} vs. 28{\%}, odds ratio 0.35, 95{\%} CI0.19-0.64). During follow-up, patients with COPD had higher mortality (73{\%} vs. 60{\%}, P = 0.016, hazard ratio 1.48, 95{\%} CI 1.15-1.90). Kaplan-Meier (log-rank test, P = 0.002) and Cox proportional hazard analysis, adjusted for age, sex, hemoglobin, uric acid, and treatment with beta-blockers and furosemide (hazard ratio 1.38, 95{\%} CI1.04-1.83, P = 0.024) demonstrated the prognostic importance of COPD. CONCLUSIONS: COPD is frequent among hospitalized patients with heart failure. Beta-blockers are largely underused, which is probably a major reason for the higher mortality observed in patients with concomitant chronic heart failure and COPD.",
keywords = "Chronic heart failure, Chronic obstructive pulmonary disease, Mortality",
author = "Mitja Lainscak and Hodoscek, {Lea Majc} and D{\"u}ngen, {Hans Dirk} and Mathias Rauchhaus and Wolfram Doehner and Anker, {Stefan D.} and {Von Haehling}, Stephan",
year = "2009",
doi = "10.1007/s00508-009-1185-8",
language = "English",
volume = "121",
pages = "309--313",
journal = "Wiener Klinische Wochenschrift",
issn = "0043-5325",
publisher = "Springer Wien",
number = "9-10",

}

TY - JOUR

T1 - The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure

AU - Lainscak, Mitja

AU - Hodoscek, Lea Majc

AU - Düngen, Hans Dirk

AU - Rauchhaus, Mathias

AU - Doehner, Wolfram

AU - Anker, Stefan D.

AU - Von Haehling, Stephan

PY - 2009

Y1 - 2009

N2 - OBJECTIVES: Like chronic heart failure, chronic obstructive pulmonary disease (COPD) is an enormous public health problem in industrialized countries. Our aim was to determine the prevalence and clinical impact of COPD among patients hospitalized for heart failure in a community hospital serving a population of 125,000 people. METHODS: Between 2001 and 2003 a total of 638 patients (73 ± 10 years, 48% men, 74% NYHA class III) were identified with a discharge diagnosis of heart failure. Medical charts were reviewed and vital status was obtained from a Central Population Registry. RESULTS: COPD was diagnosed in 106 (17%) patients whose age was similar to those without COPD (73 ± 9 vs. 73 ± 11 years, P = 0.35). Patients with COPD were more often males (65% vs. 45%, P <0.001). There were no differences in arterial hypertension, atrial fibrillation, diabetes mellitus and most laboratory markers except hemoglobin (141 ± 20 vs. 132 ± 20 g/l, P <0.001) and uric acid (453 ± 136 vs. 414 ± 139 mmol/l, P = 0.013). At discharge, patients with COPD were less likely to receive beta-blockers (12% vs. 28%, odds ratio 0.35, 95% CI0.19-0.64). During follow-up, patients with COPD had higher mortality (73% vs. 60%, P = 0.016, hazard ratio 1.48, 95% CI 1.15-1.90). Kaplan-Meier (log-rank test, P = 0.002) and Cox proportional hazard analysis, adjusted for age, sex, hemoglobin, uric acid, and treatment with beta-blockers and furosemide (hazard ratio 1.38, 95% CI1.04-1.83, P = 0.024) demonstrated the prognostic importance of COPD. CONCLUSIONS: COPD is frequent among hospitalized patients with heart failure. Beta-blockers are largely underused, which is probably a major reason for the higher mortality observed in patients with concomitant chronic heart failure and COPD.

AB - OBJECTIVES: Like chronic heart failure, chronic obstructive pulmonary disease (COPD) is an enormous public health problem in industrialized countries. Our aim was to determine the prevalence and clinical impact of COPD among patients hospitalized for heart failure in a community hospital serving a population of 125,000 people. METHODS: Between 2001 and 2003 a total of 638 patients (73 ± 10 years, 48% men, 74% NYHA class III) were identified with a discharge diagnosis of heart failure. Medical charts were reviewed and vital status was obtained from a Central Population Registry. RESULTS: COPD was diagnosed in 106 (17%) patients whose age was similar to those without COPD (73 ± 9 vs. 73 ± 11 years, P = 0.35). Patients with COPD were more often males (65% vs. 45%, P <0.001). There were no differences in arterial hypertension, atrial fibrillation, diabetes mellitus and most laboratory markers except hemoglobin (141 ± 20 vs. 132 ± 20 g/l, P <0.001) and uric acid (453 ± 136 vs. 414 ± 139 mmol/l, P = 0.013). At discharge, patients with COPD were less likely to receive beta-blockers (12% vs. 28%, odds ratio 0.35, 95% CI0.19-0.64). During follow-up, patients with COPD had higher mortality (73% vs. 60%, P = 0.016, hazard ratio 1.48, 95% CI 1.15-1.90). Kaplan-Meier (log-rank test, P = 0.002) and Cox proportional hazard analysis, adjusted for age, sex, hemoglobin, uric acid, and treatment with beta-blockers and furosemide (hazard ratio 1.38, 95% CI1.04-1.83, P = 0.024) demonstrated the prognostic importance of COPD. CONCLUSIONS: COPD is frequent among hospitalized patients with heart failure. Beta-blockers are largely underused, which is probably a major reason for the higher mortality observed in patients with concomitant chronic heart failure and COPD.

KW - Chronic heart failure

KW - Chronic obstructive pulmonary disease

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=69549086553&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69549086553&partnerID=8YFLogxK

U2 - 10.1007/s00508-009-1185-8

DO - 10.1007/s00508-009-1185-8

M3 - Article

C2 - 19562292

AN - SCOPUS:69549086553

VL - 121

SP - 309

EP - 313

JO - Wiener Klinische Wochenschrift

JF - Wiener Klinische Wochenschrift

SN - 0043-5325

IS - 9-10

ER -