The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study

Mario Mascalchi, Andrea Ginestroni, Nicola Toschi, Anna Poggesi, Paolo Cecchi, Emilia Salvadori, Carlo Tessa, Mirco Cosottini, Nicola De Stefano, Giovanni Pracucci, Leonardo Pantoni, Domenico Inzitari, Stefano Diciotti, Rosanna Abbate, Manuela Bandinelli, Maria Boddi, Francesca Cesari, Laura Ciolli, Mirella Coppo, Alessandra Del BeneBetti Giusti, Anna Maria Gori, Serena Nannucci, Marco Pasi, Francesca Pescini, Raffaella Valenti, Ubaldo Bonucelli, Alberto Chiti, Giovanni Orlandi, Cristina Pagni, Gabriele Siciliano, Gloria Tognoni, Antonio Federico, Nicola De Stefano, Maria Teresa Dotti, Patrizia Formichi, Claudia Gambetti, Antonio Giorgio, Francesca Rossi, Laura Stromillo, Enza Zicari, Paolo Zolo, Alessandro Tiezzi, Elisabetta Bertini, Stefania Brotini, Leonello Guidi, Maria Lombardi, Stefania Mugnai, Antonella Notarelli, Laura Bracco, Massimo Cadelo, Renzo Cisbani, Luciano Gabbani, Guido Gori, Lorella Lambertucci, Luca Massacesi, Enrico Mossello, Marco Paganini, Maristella Piccininni, Francesco Pinto, Claudia Pozzi, Sandro Sorbi, Gaetano Zaccara, Tiziano Borgogni, Mario Mancuso, Roberto Marconi, Monica Mazzoni, Marco Vista, Giuseppe Meucci, Giovanna Bellini, Luciano Gabrielli, Cristina Frittelli, Renato Galli, Gianna Gambaccini, Stefano Bartolini, Carlo Biagini, Veronica Caleri, Paola Vanni, Donatella Calvani, Carla Giorgi, Stefano Magnolfi, Pasquale Palumbo, Carlo Valente, Alessandro Rossi, Rossana Tassi, Stefania Boschi, Filippo Baldacci

Research output: Contribution to journalArticle

Abstract

The term leuko-araiosis (LA) describes a common chronic affection of the cerebral white matter (WM) in the elderly due to small vessel disease with variable clinical correlates. To explore whether severity of LA entails some adaptive reorganization in the cerebral cortex we evaluated with functional MRI (fMRI) the cortical activation pattern during a simple motor task in 60 subjects with mild cognitive impairment and moderate or severe (moderate-to-severe LA group, n = 46) and mild (mild LA group, n = 14) LA extension on visual rating. The microstructural damage associated with LA was measured on diffusion tensor data by computation of the mean diffusivity (MD) of the cerebral WM and by applying tract based spatial statistics (TBSS). Subjects were examined with fMRI during continuous tapping of the right dominant hand with task performance measurement. Moderate-to-severe LA group showed hyperactivation of left primary sensorimotor cortex (SM1) and right cerebellum. Regression analyses using the individual median of WM MD as explanatory variable revealed a posterior shift of activation within the left SM1 and hyperactivation of the left SMA and paracentral lobule and of the bilateral cerebellar crus. These data indicate that brain activation is modulated by increasing severity of LA with a local remapping within the SM1 and increased activity in ipsilateral nonprimary sensorimotor cortex and bilateral cerebellum. These potentially adaptive changes as well lack of contralateral cerebral hemisphere hyperactivation are in line with sparing of the U fibers and brainstem and cerebellar WM tracts and the emerging microstructual damage of the corpus callosum revealed by TBSS with increasing severity of LA.

Original languageEnglish
Pages (from-to)819-830
Number of pages12
JournalHuman Brain Mapping
Volume35
Issue number3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Diffusion tensor
  • Functional MRI
  • Leuko-araiosis
  • Motor function

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

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  • Cite this

    Mascalchi, M., Ginestroni, A., Toschi, N., Poggesi, A., Cecchi, P., Salvadori, E., Tessa, C., Cosottini, M., De Stefano, N., Pracucci, G., Pantoni, L., Inzitari, D., Diciotti, S., Abbate, R., Bandinelli, M., Boddi, M., Cesari, F., Ciolli, L., Coppo, M., ... Baldacci, F. (2014). The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study. Human Brain Mapping, 35(3), 819-830. https://doi.org/10.1002/hbm.22216