The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes

Gabriele Forlani, Carlo Giorda, Roberta Manti, Natalia Mazzella, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Paolo Di Bartolo, Antonio Ceriello, Pietro Guida

Research output: Contribution to journalArticle

Abstract

Objective. We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) and its clinical correlates in a population of patients with type 2 diabetes mellitus (T2DM). Methods. Clinical data of 94,577 T2DM patients were retrieved from 160 diabetes clinics in Italy in a standardized format and centrally analyzed anonymously. After exclusion of 5967 cases (high or uncertain alcohol intake), in 38,880 the Fatty Liver Index (FLI) was used as a proxy for the diagnosis of NAFLD. Factors associated with FLI assessed NAFLD (FLI-NAFLD) were evaluated through multivariate analysis. Results. FLI-NAFLD was present in 59.6% of patients. Compared to non-NAFLD, FLI-NAFLD was associated with impairment in renal function, higher albumin excretion, HbA1c and blood pressure, lower HDL cholesterol, and poorer quality of care. ALT was within normal limits in 73.6% of FLI-NAFLD patients (45.6% if the updated reference values were used). The prevalence of FLI-NAFLD did not differ if the whole sample (94,577 cases) was examined, irrespective of alcohol intake. Conclusions. FLI-NAFLD was present in the majority of T2DM patients of our sample and metabolic derangement, not alcohol consumption, was mainly associated with the disease. FLI-NAFLD patients have a worse metabolic profile. ALT levels are not predictive of NAFLD.

Original languageEnglish
Article number2931985
JournalJournal of Diabetes Research
Volume2016
DOIs
Publication statusPublished - 2016

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Fatty Liver
Type 2 Diabetes Mellitus
Population
Alcohols
Non-alcoholic Fatty Liver Disease
Metabolome
Quality of Health Care
Proxy
Alcohol Drinking
HDL Cholesterol
Italy
Liver Diseases
Albumins
Reference Values
Multivariate Analysis
Blood Pressure
Kidney

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes. / Forlani, Gabriele; Giorda, Carlo; Manti, Roberta; Mazzella, Natalia; De Cosmo, Salvatore; Rossi, Maria Chiara; Nicolucci, Antonio; Di Bartolo, Paolo; Ceriello, Antonio; Guida, Pietro.

In: Journal of Diabetes Research, Vol. 2016, 2931985, 2016.

Research output: Contribution to journalArticle

Forlani, G, Giorda, C, Manti, R, Mazzella, N, De Cosmo, S, Rossi, MC, Nicolucci, A, Di Bartolo, P, Ceriello, A & Guida, P 2016, 'The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes', Journal of Diabetes Research, vol. 2016, 2931985. https://doi.org/10.1155/2016/2931985
Forlani, Gabriele ; Giorda, Carlo ; Manti, Roberta ; Mazzella, Natalia ; De Cosmo, Salvatore ; Rossi, Maria Chiara ; Nicolucci, Antonio ; Di Bartolo, Paolo ; Ceriello, Antonio ; Guida, Pietro. / The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes. In: Journal of Diabetes Research. 2016 ; Vol. 2016.
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AU - Nicolucci, Antonio

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