The burden of narcolepsy with cataplexy

How disease history and clinical features influence socio-economic outcomes

Francesca Ingravallo, Valentina Gnucci, Fabio Pizza, Luca Vignatelli, Annamaria Govi, Ada Dormi, Susi Pelotti, Alberto Cicognani, Yves Dauvilliers, Giuseppe Plazzi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: To investigate in narcolepsy with cataplexy (NC) patients of working age (18-65. years) the influence of age at onset, age at diagnosis and clinical features on socio-occupational conditions, disease-related economic burden, and quality of life. Methods: One hundred consecutive patients underwent a semistructured interview on socio-occupational aspects, NC-related direct and indirect costs, and NC history. Questionnaires were used to evaluate excessive daytime sleepiness, cataplexy, depressive symptoms, and quality of life. Results: NC patients (51 males, mean age 37 ± 11.5. years) had educational and occupational levels similar to those of the Italian population of the same age range, but married less often, especially if NC onset occurred at a young age. Total annual NC-related costs were €9814 ± 10,372 per patient. Multivariate analyses showed that patients with NC onset before the age of 30. years had a higher educational level, married less frequently, and were less frequently unemployed or inactive (retired, housewife). Patients diagnosed before the age of 30. years were less frequently unemployed or inactive, had fewer work changes, and had a better general health perception. Irresistible sleepiness was associated with work absences and higher indirect costs. Depressive symptoms were strongly associated with lower quality-of-life scores. Conclusions: NC age at onset and at diagnosis modulates the disease-related burden. A diagnosis at a young age could improve patients' occupational prognosis, and their general health perception.

Original languageEnglish
Pages (from-to)1293-1300
Number of pages8
JournalSleep Medicine
Volume13
Issue number10
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Cataplexy
Narcolepsy
Economics
Age of Onset
Quality of Life
Costs and Cost Analysis
Depression
Occupational Diseases
Health
Multivariate Analysis
History
Interviews

Keywords

  • Disease history
  • Economic costs
  • Excessive daytime sleepiness
  • Narcolepsy with cataplexy
  • Quality of life
  • Work disability

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The burden of narcolepsy with cataplexy : How disease history and clinical features influence socio-economic outcomes. / Ingravallo, Francesca; Gnucci, Valentina; Pizza, Fabio; Vignatelli, Luca; Govi, Annamaria; Dormi, Ada; Pelotti, Susi; Cicognani, Alberto; Dauvilliers, Yves; Plazzi, Giuseppe.

In: Sleep Medicine, Vol. 13, No. 10, 12.2012, p. 1293-1300.

Research output: Contribution to journalArticle

Ingravallo, F, Gnucci, V, Pizza, F, Vignatelli, L, Govi, A, Dormi, A, Pelotti, S, Cicognani, A, Dauvilliers, Y & Plazzi, G 2012, 'The burden of narcolepsy with cataplexy: How disease history and clinical features influence socio-economic outcomes', Sleep Medicine, vol. 13, no. 10, pp. 1293-1300. https://doi.org/10.1016/j.sleep.2012.08.002
Ingravallo, Francesca ; Gnucci, Valentina ; Pizza, Fabio ; Vignatelli, Luca ; Govi, Annamaria ; Dormi, Ada ; Pelotti, Susi ; Cicognani, Alberto ; Dauvilliers, Yves ; Plazzi, Giuseppe. / The burden of narcolepsy with cataplexy : How disease history and clinical features influence socio-economic outcomes. In: Sleep Medicine. 2012 ; Vol. 13, No. 10. pp. 1293-1300.
@article{3195ca737b224ce2acd2376152e935d6,
title = "The burden of narcolepsy with cataplexy: How disease history and clinical features influence socio-economic outcomes",
abstract = "Objective: To investigate in narcolepsy with cataplexy (NC) patients of working age (18-65. years) the influence of age at onset, age at diagnosis and clinical features on socio-occupational conditions, disease-related economic burden, and quality of life. Methods: One hundred consecutive patients underwent a semistructured interview on socio-occupational aspects, NC-related direct and indirect costs, and NC history. Questionnaires were used to evaluate excessive daytime sleepiness, cataplexy, depressive symptoms, and quality of life. Results: NC patients (51 males, mean age 37 ± 11.5. years) had educational and occupational levels similar to those of the Italian population of the same age range, but married less often, especially if NC onset occurred at a young age. Total annual NC-related costs were €9814 ± 10,372 per patient. Multivariate analyses showed that patients with NC onset before the age of 30. years had a higher educational level, married less frequently, and were less frequently unemployed or inactive (retired, housewife). Patients diagnosed before the age of 30. years were less frequently unemployed or inactive, had fewer work changes, and had a better general health perception. Irresistible sleepiness was associated with work absences and higher indirect costs. Depressive symptoms were strongly associated with lower quality-of-life scores. Conclusions: NC age at onset and at diagnosis modulates the disease-related burden. A diagnosis at a young age could improve patients' occupational prognosis, and their general health perception.",
keywords = "Disease history, Economic costs, Excessive daytime sleepiness, Narcolepsy with cataplexy, Quality of life, Work disability",
author = "Francesca Ingravallo and Valentina Gnucci and Fabio Pizza and Luca Vignatelli and Annamaria Govi and Ada Dormi and Susi Pelotti and Alberto Cicognani and Yves Dauvilliers and Giuseppe Plazzi",
year = "2012",
month = "12",
doi = "10.1016/j.sleep.2012.08.002",
language = "English",
volume = "13",
pages = "1293--1300",
journal = "Sleep Medicine",
issn = "1389-9457",
publisher = "Elsevier",
number = "10",

}

TY - JOUR

T1 - The burden of narcolepsy with cataplexy

T2 - How disease history and clinical features influence socio-economic outcomes

AU - Ingravallo, Francesca

AU - Gnucci, Valentina

AU - Pizza, Fabio

AU - Vignatelli, Luca

AU - Govi, Annamaria

AU - Dormi, Ada

AU - Pelotti, Susi

AU - Cicognani, Alberto

AU - Dauvilliers, Yves

AU - Plazzi, Giuseppe

PY - 2012/12

Y1 - 2012/12

N2 - Objective: To investigate in narcolepsy with cataplexy (NC) patients of working age (18-65. years) the influence of age at onset, age at diagnosis and clinical features on socio-occupational conditions, disease-related economic burden, and quality of life. Methods: One hundred consecutive patients underwent a semistructured interview on socio-occupational aspects, NC-related direct and indirect costs, and NC history. Questionnaires were used to evaluate excessive daytime sleepiness, cataplexy, depressive symptoms, and quality of life. Results: NC patients (51 males, mean age 37 ± 11.5. years) had educational and occupational levels similar to those of the Italian population of the same age range, but married less often, especially if NC onset occurred at a young age. Total annual NC-related costs were €9814 ± 10,372 per patient. Multivariate analyses showed that patients with NC onset before the age of 30. years had a higher educational level, married less frequently, and were less frequently unemployed or inactive (retired, housewife). Patients diagnosed before the age of 30. years were less frequently unemployed or inactive, had fewer work changes, and had a better general health perception. Irresistible sleepiness was associated with work absences and higher indirect costs. Depressive symptoms were strongly associated with lower quality-of-life scores. Conclusions: NC age at onset and at diagnosis modulates the disease-related burden. A diagnosis at a young age could improve patients' occupational prognosis, and their general health perception.

AB - Objective: To investigate in narcolepsy with cataplexy (NC) patients of working age (18-65. years) the influence of age at onset, age at diagnosis and clinical features on socio-occupational conditions, disease-related economic burden, and quality of life. Methods: One hundred consecutive patients underwent a semistructured interview on socio-occupational aspects, NC-related direct and indirect costs, and NC history. Questionnaires were used to evaluate excessive daytime sleepiness, cataplexy, depressive symptoms, and quality of life. Results: NC patients (51 males, mean age 37 ± 11.5. years) had educational and occupational levels similar to those of the Italian population of the same age range, but married less often, especially if NC onset occurred at a young age. Total annual NC-related costs were €9814 ± 10,372 per patient. Multivariate analyses showed that patients with NC onset before the age of 30. years had a higher educational level, married less frequently, and were less frequently unemployed or inactive (retired, housewife). Patients diagnosed before the age of 30. years were less frequently unemployed or inactive, had fewer work changes, and had a better general health perception. Irresistible sleepiness was associated with work absences and higher indirect costs. Depressive symptoms were strongly associated with lower quality-of-life scores. Conclusions: NC age at onset and at diagnosis modulates the disease-related burden. A diagnosis at a young age could improve patients' occupational prognosis, and their general health perception.

KW - Disease history

KW - Economic costs

KW - Excessive daytime sleepiness

KW - Narcolepsy with cataplexy

KW - Quality of life

KW - Work disability

UR - http://www.scopus.com/inward/record.url?scp=84870522806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870522806&partnerID=8YFLogxK

U2 - 10.1016/j.sleep.2012.08.002

DO - 10.1016/j.sleep.2012.08.002

M3 - Article

VL - 13

SP - 1293

EP - 1300

JO - Sleep Medicine

JF - Sleep Medicine

SN - 1389-9457

IS - 10

ER -