The cadaver kidney transplantation programme of milano: Immunologicall report

Girolamo Sirchia, Francesco Mercuriali, Mario Scalamogna, Vittorio Rosso di San Secondo, Claudia Pizzi, Francesca Poli

Research output: Contribution to journalArticle

Abstract

A retrospective investigation was carried out to evaluate the influence of HLA (A, B) matching, blood transfusions, and preexistence of lymphocytotoxic antibodies on the outcome of the cadaver kidney graft: Only non-NIH standard antibodies were considered, since patients with NIH standard antibodies do not undergo transplantation in the programme of Milano. It was found that (1) about one-half the patients with transplants had antibodies in their pretransplant serum. The preexistence of antibodies directed against B lymphocytes had an unfavourable effect on the graft survival; (2) the graft did particularly well in the nonimmunized patients who had been previously transfused; the graft survival was about 80% at 3 years in these patients; and (3) the HLA (A, B) match influenced the graft survival only in patients with antibodies.

Original languageEnglish
Pages (from-to)391-395
Number of pages5
JournalTransplantation
Volume23
Issue number5
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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    Sirchia, G., Mercuriali, F., Scalamogna, M., di San Secondo, V. R., Pizzi, C., & Poli, F. (1977). The cadaver kidney transplantation programme of milano: Immunologicall report. Transplantation, 23(5), 391-395.