The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy

Maria Franzini, Valentina Lorenzoni, Silvia Masotti, Concetta Prontera, Dante Chiappino, Daniele Della Latta, Massimo Daves, Irene Deluggi, Massimo Zuin, Luigina Ferrigno, Alfonso Mele, Fabrizio Marcucci, Carmelo A. Caserta, Pasquale Surace, Arianna Messineo, Giuseppe Turchetti, Claudio Passino, Michele Emdin, Aldo Clerico

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: The aim of this study is to determine the 99th upper-reference limit (URL) for cardiac troponin T (cTnT) in Italian apparently healthy subjects. Methods: The reference population was selected from 5 cities: Bolzano (n = 290), Milano (CAMELIA-Study, n = 287), Montignoso (MEHLP-Study, n = 306), Pisa (n = 182), and Reggio Calabria (MAREA-Study, n = 535). Subjects having cardiac/systemic acute/chronic diseases were excluded. Participants to MEHLP project underwent cardiac imaging investigation. High-sensitive cTnT was measured with Cobas-e411 (Roche Diagnostics). Results: We enrolled 1600 healthy subjects [54.6% males; age range 10-90. years; mean (SD): 36.4 (21.2) years], including 34.6% aged

Original languageEnglish
Pages (from-to)376-381
Number of pages6
JournalClinica Chimica Acta
Volume438
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Troponin T
Italy
Multicenter Studies
Healthy Volunteers
Acute Disease
Population
Chronic Disease
Imaging techniques

Keywords

  • 99th upper reference limit
  • Cardiac troponin T
  • Outlier calculation
  • Reference population

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)

Cite this

The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection : A multicenter study in Italy. / Franzini, Maria; Lorenzoni, Valentina; Masotti, Silvia; Prontera, Concetta; Chiappino, Dante; Latta, Daniele Della; Daves, Massimo; Deluggi, Irene; Zuin, Massimo; Ferrigno, Luigina; Mele, Alfonso; Marcucci, Fabrizio; Caserta, Carmelo A.; Surace, Pasquale; Messineo, Arianna; Turchetti, Giuseppe; Passino, Claudio; Emdin, Michele; Clerico, Aldo.

In: Clinica Chimica Acta, Vol. 438, 01.01.2015, p. 376-381.

Research output: Contribution to journalArticle

Franzini, M, Lorenzoni, V, Masotti, S, Prontera, C, Chiappino, D, Latta, DD, Daves, M, Deluggi, I, Zuin, M, Ferrigno, L, Mele, A, Marcucci, F, Caserta, CA, Surace, P, Messineo, A, Turchetti, G, Passino, C, Emdin, M & Clerico, A 2015, 'The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy', Clinica Chimica Acta, vol. 438, pp. 376-381. https://doi.org/10.1016/j.cca.2014.09.010
Franzini, Maria ; Lorenzoni, Valentina ; Masotti, Silvia ; Prontera, Concetta ; Chiappino, Dante ; Latta, Daniele Della ; Daves, Massimo ; Deluggi, Irene ; Zuin, Massimo ; Ferrigno, Luigina ; Mele, Alfonso ; Marcucci, Fabrizio ; Caserta, Carmelo A. ; Surace, Pasquale ; Messineo, Arianna ; Turchetti, Giuseppe ; Passino, Claudio ; Emdin, Michele ; Clerico, Aldo. / The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection : A multicenter study in Italy. In: Clinica Chimica Acta. 2015 ; Vol. 438. pp. 376-381.
@article{ed7140fafb1a41e0875e8480b648c039,
title = "The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy",
abstract = "Background: The aim of this study is to determine the 99th upper-reference limit (URL) for cardiac troponin T (cTnT) in Italian apparently healthy subjects. Methods: The reference population was selected from 5 cities: Bolzano (n = 290), Milano (CAMELIA-Study, n = 287), Montignoso (MEHLP-Study, n = 306), Pisa (n = 182), and Reggio Calabria (MAREA-Study, n = 535). Subjects having cardiac/systemic acute/chronic diseases were excluded. Participants to MEHLP project underwent cardiac imaging investigation. High-sensitive cTnT was measured with Cobas-e411 (Roche Diagnostics). Results: We enrolled 1600 healthy subjects [54.6{\%} males; age range 10-90. years; mean (SD): 36.4 (21.2) years], including 34.6{\%} aged",
keywords = "99th upper reference limit, Cardiac troponin T, Outlier calculation, Reference population",
author = "Maria Franzini and Valentina Lorenzoni and Silvia Masotti and Concetta Prontera and Dante Chiappino and Latta, {Daniele Della} and Massimo Daves and Irene Deluggi and Massimo Zuin and Luigina Ferrigno and Alfonso Mele and Fabrizio Marcucci and Caserta, {Carmelo A.} and Pasquale Surace and Arianna Messineo and Giuseppe Turchetti and Claudio Passino and Michele Emdin and Aldo Clerico",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.cca.2014.09.010",
language = "English",
volume = "438",
pages = "376--381",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",

}

TY - JOUR

T1 - The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection

T2 - A multicenter study in Italy

AU - Franzini, Maria

AU - Lorenzoni, Valentina

AU - Masotti, Silvia

AU - Prontera, Concetta

AU - Chiappino, Dante

AU - Latta, Daniele Della

AU - Daves, Massimo

AU - Deluggi, Irene

AU - Zuin, Massimo

AU - Ferrigno, Luigina

AU - Mele, Alfonso

AU - Marcucci, Fabrizio

AU - Caserta, Carmelo A.

AU - Surace, Pasquale

AU - Messineo, Arianna

AU - Turchetti, Giuseppe

AU - Passino, Claudio

AU - Emdin, Michele

AU - Clerico, Aldo

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: The aim of this study is to determine the 99th upper-reference limit (URL) for cardiac troponin T (cTnT) in Italian apparently healthy subjects. Methods: The reference population was selected from 5 cities: Bolzano (n = 290), Milano (CAMELIA-Study, n = 287), Montignoso (MEHLP-Study, n = 306), Pisa (n = 182), and Reggio Calabria (MAREA-Study, n = 535). Subjects having cardiac/systemic acute/chronic diseases were excluded. Participants to MEHLP project underwent cardiac imaging investigation. High-sensitive cTnT was measured with Cobas-e411 (Roche Diagnostics). Results: We enrolled 1600 healthy subjects [54.6% males; age range 10-90. years; mean (SD): 36.4 (21.2) years], including 34.6% aged

AB - Background: The aim of this study is to determine the 99th upper-reference limit (URL) for cardiac troponin T (cTnT) in Italian apparently healthy subjects. Methods: The reference population was selected from 5 cities: Bolzano (n = 290), Milano (CAMELIA-Study, n = 287), Montignoso (MEHLP-Study, n = 306), Pisa (n = 182), and Reggio Calabria (MAREA-Study, n = 535). Subjects having cardiac/systemic acute/chronic diseases were excluded. Participants to MEHLP project underwent cardiac imaging investigation. High-sensitive cTnT was measured with Cobas-e411 (Roche Diagnostics). Results: We enrolled 1600 healthy subjects [54.6% males; age range 10-90. years; mean (SD): 36.4 (21.2) years], including 34.6% aged

KW - 99th upper reference limit

KW - Cardiac troponin T

KW - Outlier calculation

KW - Reference population

UR - http://www.scopus.com/inward/record.url?scp=84908269149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908269149&partnerID=8YFLogxK

U2 - 10.1016/j.cca.2014.09.010

DO - 10.1016/j.cca.2014.09.010

M3 - Article

C2 - 25239669

AN - SCOPUS:84908269149

VL - 438

SP - 376

EP - 381

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -