The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy

Maria Franzini, Valentina Lorenzoni, Silvia Masotti, Concetta Prontera, Dante Chiappino, Daniele Della Latta, Massimo Daves, Irene Deluggi, Massimo Zuin, Luigina Ferrigno, Alfonso Mele, Fabrizio Marcucci, Carmelo A. Caserta, Pasquale Surace, Arianna Messineo, Giuseppe Turchetti, Claudio Passino, Michele Emdin, Aldo Clerico

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study is to determine the 99th upper-reference limit (URL) for cardiac troponin T (cTnT) in Italian apparently healthy subjects. Methods: The reference population was selected from 5 cities: Bolzano (n = 290), Milano (CAMELIA-Study, n = 287), Montignoso (MEHLP-Study, n = 306), Pisa (n = 182), and Reggio Calabria (MAREA-Study, n = 535). Subjects having cardiac/systemic acute/chronic diseases were excluded. Participants to MEHLP project underwent cardiac imaging investigation. High-sensitive cTnT was measured with Cobas-e411 (Roche Diagnostics). Results: We enrolled 1600 healthy subjects [54.6% males; age range 10-90. years; mean (SD): 36.4 (21.2) years], including 34.6% aged

Original languageEnglish
Pages (from-to)376-381
Number of pages6
JournalClinica Chimica Acta
Volume438
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • 99th upper reference limit
  • Cardiac troponin T
  • Outlier calculation
  • Reference population

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)

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