@article{900758af895d4342a2d5b35f71d89cdb,
title = "The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma",
abstract = "Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival.",
keywords = "CDKN2A, DNA hypermethylation, PanCanAtlas, TCGA, chromatin remodeling, chromophobe renal cell carcinoma, clear cell renal cell carcinoma, immune signature, papillary renal cell carcinoma",
author = "Ricketts, {C. J.} and Cubas, {A. A. De} and H. Fan and Smith, {C. C.} and M. Lang and E. Reznik and R. Bowlby and Gibb, {E. A.} and R. Akbani and R. Beroukhim and Bottaro, {D. P.} and Choueiri, {T. K.} and Gibbs, {R. A.} and Godwin, {A. K.} and S. Haake and Hakimi, {A. A.} and Henske, {E. P.} and Hsieh, {J. J.} and Ho, {T. H.} and Kanchi, {R. S.} and B. Krishnan and Kwiatkowski, {D. J.} and W. Lui and Merino, {M. J.} and Mills, {G. B.} and J. Myers and Nickerson, {M. L.} and Reuter, {V. E.} and Schmidt, {L. S.} and Shelley, {C. S.} and H. Shen and B. Shuch and S. Signoretti and R. Srinivasan and P. Tamboli and G. Thomas and Vincent, {B. G.} and Vocke, {C. D.} and Wheeler, {D. A.} and L. Yang and Kim, {W. Y.} and Robertson, {A. G.} and Network, {Cancer Genome Atlas Research} and Spellman, {P. T.} and Rathmell, {W. K.} and Linehan, {W. M.}",
note = "LR: 20180808; CI: Published by Elsevier Inc.; GR: P30 CA016672/CA/NCI NIH HHS/United States; GR: U24 CA143882/CA/NCI NIH HHS/United States; GR: U54 HG003067/HG/NHGRI NIH HHS/United States; GR: U24 CA143835/CA/NCI NIH HHS/United States; GR: K12 CA090625/CA/NCI NIH HHS/United States; GR: U24 CA143866/CA/NCI NIH HHS/United States; GR: U24 CA210950/CA/NCI NIH HHS/United States; GR: U24 CA143845/CA/NCI NIH HHS/United States; GR: U24 CA143799/CA/NCI NIH HHS/United States; GR: U54 HG003273/HG/NHGRI NIH HHS/United States; GR: U24 CA144025/CA/NCI NIH HHS/United States; GR: U24 CA143840/CA/NCI NIH HHS/United States; GR: U24 CA143843/CA/NCI NIH HHS/United States; GR: U24 CA143858/CA/NCI NIH HHS/United States; GR: U24 CA143848/CA/NCI NIH HHS/United States; GR: U54 HG003079/HG/NHGRI NIH HHS/United States; GR: U24 CA210949/CA/NCI NIH HHS/United States; GR: U24 CA143883/CA/NCI NIH HHS/United States; GR: HHSN261200800001C/RC/CCR NIH HHS/United States; GR: U24 CA143867/CA/NCI NIH HHS/United States; GR: HHSN261200800001E/CA/NCI NIH HHS/United States; JID: 101573691; EIN: Cell Rep. 2018 Jun 19;23(12):3698. PMID: 29925010; NIHMS958988; OTO: NOTNLM; 2017/09/26 00:00 [received]; 2018/03/09 00:00 [revised]; 2018/03/19 00:00 [accepted]; 2018/04/05 06:00 [entrez]; 2018/04/05 06:00 [pubmed]; 2018/04/05 06:00 [medline]; ppublish",
year = "2018",
month = apr,
day = "3",
doi = "S2211-1247(18)30436-4 [pii]",
language = "English",
volume = "23",
pages = "313--326.e5",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}