The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation

Implications for bone health

Aoife Gowran, Katey McKayed, Veronica A. Campbell

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Significant loss of bone due to trauma, underlying metabolic disease, or lack of repair due to old age surpasses the body's endogenous bone repair mechanisms. Mesenchymal stem cells (MSCs) are adult stem cells which may represent an ideal cell type for use in cell-based tissue engineered bone regeneration strategies. The body's endocannabinoid system has been identified as a central regulator of bone metabolism. The aim of the study was to elucidate the role of the cannabinoid receptor type 1 in the differentiation and survival of MSCs. We show that the cannabinoid receptor type 1 has a prosurvival function during acute cell stress. Additionally, we show that the phytocannabinoid, Δ 9 -Tetrahydrocannabinol, has a negative impact on MSC survival and osteogenesis. Overall, these results show the potential for the modulation of the cannabinoid system in cell-based tissue engineered bone regeneration strategies whilst highlighting cannabis use as a potential cause for concern in the management of orthopaedic patients.

Original languageEnglish
Article number796715
JournalStem Cells International
DOIs
Publication statusPublished - 2013

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Cannabinoid Receptors
Mesenchymal Stromal Cells
Cell Differentiation
Cell Survival
Bone and Bones
Bone Regeneration
Health
Endocannabinoids
Adult Stem Cells
Dronabinol
Cannabinoids
Metabolic Diseases
Cannabis
Osteogenesis
Orthopedics
Wounds and Injuries

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

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