TY - JOUR
T1 - The cannabinoids switch of oxidative stress
T2 - A double-edged sword
AU - Borro, Marina
AU - Frati, Paola
AU - Di Luca, Natale Mario
AU - Simmaco, Maurizio
AU - Ferracuti, Stefano
PY - 2013
Y1 - 2013
N2 - Oxidative Stress, deriving from a perturbation of the cellular balance between pro-oxidant and anti-oxidant molecules, has been involved in the patho-physiology of multiple diseases, and anti-oxidant supplementation are largely studied for therapeutic purposes. The Cannabis sativa derivates, the cannabinoids (CBs), are widely used as a recreational drug, but pharmacological activities also prompt to therapeutic use. Exposure to CBs rises physical and psychic effects which can evolve in both short-term and long-term toxicity. High inter-individual variation exists in the susceptibility to these effects. Many evidences show a complex modulator action of CBs on cellular oxidative stress, with different outcomes according to cellular type, microenvironment, time and dose of exposition. The subtle balance between anti-oxidant or pro-oxidant action of CBs should be taken into account to achieve a more accurate comprehension of the molecular mechanisms involved in toxicity, considering that OS is not merely a damaging factor, but is also involved in protective pathways.
AB - Oxidative Stress, deriving from a perturbation of the cellular balance between pro-oxidant and anti-oxidant molecules, has been involved in the patho-physiology of multiple diseases, and anti-oxidant supplementation are largely studied for therapeutic purposes. The Cannabis sativa derivates, the cannabinoids (CBs), are widely used as a recreational drug, but pharmacological activities also prompt to therapeutic use. Exposure to CBs rises physical and psychic effects which can evolve in both short-term and long-term toxicity. High inter-individual variation exists in the susceptibility to these effects. Many evidences show a complex modulator action of CBs on cellular oxidative stress, with different outcomes according to cellular type, microenvironment, time and dose of exposition. The subtle balance between anti-oxidant or pro-oxidant action of CBs should be taken into account to achieve a more accurate comprehension of the molecular mechanisms involved in toxicity, considering that OS is not merely a damaging factor, but is also involved in protective pathways.
KW - Cannabinoids
KW - Cannabis
KW - Genomics
KW - Oxidative stress
KW - Polymorphisms
KW - Psychosis
UR - http://www.scopus.com/inward/record.url?scp=84892971304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892971304&partnerID=8YFLogxK
U2 - 10.2174/1570193X113106660024
DO - 10.2174/1570193X113106660024
M3 - Article
AN - SCOPUS:84892971304
VL - 10
SP - 343
EP - 348
JO - Mini-Reviews in Organic Chemistry
JF - Mini-Reviews in Organic Chemistry
SN - 1570-193X
IS - 4
ER -