The capillary lobule: A deceptively benign feature of post-radiation angiosarcoma of the skin - Report of three cases

Luca Di Tommaso, Juan Rosai

Research output: Contribution to journalArticlepeer-review

Abstract

Three cases are presented of a proliferative vascular lesion of the skin developing in the chest wall of women who had received radiation therapy for breast carcinoma. All 3 lesions were characterized microscopically by the presence of the so-called capillary lobule, a formation generally regarded as a sign of benignancy but that in this setting proved to be a forerunner or indicator of angiosarcoma (malignant hemangioendothelioma). Therefore, the detection of capillary lobules in irradiated skin ought to be regarded with great suspicion, and other morphologic signs suggestive of angiosarcoma should be sought in the specimen.

Original languageEnglish
Pages (from-to)301-305
Number of pages5
JournalAmerican Journal of Dermatopathology
Volume27
Issue number4
DOIs
Publication statusPublished - Aug 2005

Keywords

  • Angiosarcoma
  • Capillary lobule
  • Malignant hemangio-endothelioma
  • Post-radiation sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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