The captopril test in children with renovascular and renal hypertension

E. Fossali, R. Intermite, M. Minoja, S. Tirelli, F. Sereni

Research output: Contribution to journalArticlepeer-review


We used the captopril test (CT) in 32 children, 8 with renovascular hypertension (RVH), 17 with renal hypertension (RH) and 7 with normal blood pressure, in order to study the renin-angiotensin system activation (RASA). All children affected by RVH presented a positive CT: a post-captopril plasma renin activity (PRA) of 12 ng ml -1 h -1 or more, an absolute PRA increase of 10 ng ml -1 h -1 or more and a 150% increase or more, or 400% or more if the baseline PRA was less than 3 ng ml -1 h -1. The CT may be useful for demonstrating the RASA in RVH.

Original languageEnglish
Pages (from-to)1129-1131
Number of pages3
JournalActa Paediatrica, International Journal of Paediatrics
Issue number9
Publication statusPublished - 1996


  • Captopril test
  • Plasma renin activity
  • Renovascular hypertension

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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