The cardiovascular risk of young women with polycystic ovary syndrome: An observational, analytical, prospective case-control study

Francesco Orio, Stefano Palomba, Letizia Spinelli, Teresa Cascella, Libuse Tauchmanovà, Fulvio Zullo, Gaetano Lombardi, Annamaria Colao

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the cardiovascular risk of polycystic ovary syndrome (PCOS), we investigated lipid profile, metabolic pattern, and echocardiography in 30 young women with PCOS and 30 healthy age- and body mass index (BMI)-matched women. PCOS women had higher fasting glucose and insulin levels, homeostasis model assessment score of insulin sensitivity, total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels, and TC/high density lipoprotein cholesterol (HDL-C) ratio and lower HDL-C levels than controls. Additionally, PCOS women had higher left atrium size (32.0 ± 4.9 vs. 27.4 ± 2.1 mm; P <0.0001) and left ventricular mass index (80.5 ± 18.1 vs. 56.1 ± 5.4 g/m2; P <0.0001) and lower left ventricular ejection fraction (64.4 ± 4.1 vs. 67.1 ± 2.6%; P = 0.003) and early to late mitral flow velocity ratio (1.6 ± 0.4 vs. 2.1 ± 0.2; P <0.0001) than controls. When patients and controls were grouped according to BMI [normal weight (BMI, >18 and 2), overweight (BMI, 25.1-30 kg/m2), and obese (BMI, >30 kg/m2)], the differences between PCOS women and controls were maintained in overweight and obese women. In normal weight PCOS women, a significant increase in left ventricular mass indes and a decrease in diastolic filling were observed, notwithstanding no change in TC, LDL-C, HDL-C, TC/HDL-C ratio, and TG compared with controls. In conclusion, our data show the detrimental effect of PCOS on the cardiovascular system even in young women asymptomatic for cardiac disease.

Original languageEnglish
Pages (from-to)3696-3701
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number8
DOIs
Publication statusPublished - Aug 2004

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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