TY - JOUR
T1 - The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations
AU - Capurso, Cristiano
AU - Solfrizzi, Vincenzo
AU - D'Introno, Alessia
AU - Colacicco, Anna M.
AU - Capurso, Sabrina A.
AU - Mastroianni, Franco
AU - Liaci, Maria
AU - Vendemiale, Gianluigi
AU - Capurso, Antonio
AU - Panza, Francesco
PY - 2005/8
Y1 - 2005/8
N2 - The cathepsin D gene (CTSD) exon 2 (C224T) polymorphism has been associated with an increased risk for sporadic Alzheimer's disease (AD), but with controversial findings. We studied CTSD exon 2 (C224T) and apolipoprotein E (APOE) genotype frequencies in 168 AD patients and 218 age-matched healthy controls from Southern Italy. No statistically significant differences were found in CTSD allele or genotype frequencies between AD patients and controls, and there were no interactions with sex or APOE genotype. Furthermore, comparing our results with the findings from other European populations, the CTSD*T allele frequency showed a statistically significant increasing trend from Northern to Southern regions of Europe in AD patients and controls (z = 2.51, p <.01; z = 4.02, p <.001, respectively), with a concomitant inverse trend for CTSD*C allele frequency. The regional differences in CTSD allele frequencies could be related to the different patterns of association between this polymorphism and AD in various European studies.
AB - The cathepsin D gene (CTSD) exon 2 (C224T) polymorphism has been associated with an increased risk for sporadic Alzheimer's disease (AD), but with controversial findings. We studied CTSD exon 2 (C224T) and apolipoprotein E (APOE) genotype frequencies in 168 AD patients and 218 age-matched healthy controls from Southern Italy. No statistically significant differences were found in CTSD allele or genotype frequencies between AD patients and controls, and there were no interactions with sex or APOE genotype. Furthermore, comparing our results with the findings from other European populations, the CTSD*T allele frequency showed a statistically significant increasing trend from Northern to Southern regions of Europe in AD patients and controls (z = 2.51, p <.01; z = 4.02, p <.001, respectively), with a concomitant inverse trend for CTSD*C allele frequency. The regional differences in CTSD allele frequencies could be related to the different patterns of association between this polymorphism and AD in various European studies.
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M3 - Article
C2 - 16127101
AN - SCOPUS:24144488316
VL - 60
SP - 991
EP - 996
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 8
ER -