The CD5+ B-cell

Mariella Dono, Giannamaria Cerruti, Simona Zupo

Research output: Contribution to journalArticlepeer-review


In the last two decades, many efforts have been made to better understand the biology of B-lymphoproliferative disorders through the knowledge of physiology and function of the postulated normal counterpart. The follicular mantle B-cells express a typical CD23+ IgM+ IgD+ phenotype and surround the germinal center area in secondary lymphoid organs. CD5+ B-cells with FM phenotype can be isolated from different sources and all share similar morphologic, phenotypic and functional features (small cells, scanty nucleus/cytoplasm ratio, unmutated VH genes, response to polyclonal activators but not to T independent antigens, production of "natural" antibodies). While the CD5+ B-cells predominate in fetal life, their number decreases with age. However, the CD5+ B-cells have been demonstrated to increase again in elderly both in man and mouse. This finding may explain the incidence of B-CLL and of MCL that are believed to represent the malignant transformation of the normal CD5+ B-cells, among elderly and middle aged individuals, respectively. Cell facts A major function of CD5+ B-cells is to produce low-affinity polyreactive antibodies; CD5+ cells comprise 15-25% of the B-cell population in adult secondary lymphoid organs; They mostly display a follicular mantle phenotype (CD23+ IgM+ IgD+); They are indicated as a self-replenishing B-cell subpopulation; CD5+ B-cells show an increased propensity to malignant transformation.

Original languageEnglish
Pages (from-to)2105-2111
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
Issue number11
Publication statusPublished - Nov 2004


  • Autoantibodies
  • B-cell chronic lymphocytic leukemia
  • CD5+ B-cells
  • Mantle cell lymphoma

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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