The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

Roberto Testi, Daniele D'Ambrosio, Ruggero De Maria, Angela Santoni

Research output: Contribution to journalArticlepeer-review


CD69 was initially described as being restricted to recently activated lymphoid cells, but is now known to be expressed on the surface of all hematopoietically derived leukocytes. Crosslinking of CD69 generates intracellular signals in all cell lineages studied, both mouse and human, and results in a variety of cellular end responses. Since a specific ligand has not yet been identified, a definite functional identity for CD69 is still missing. However, as discussed here by Roberto Testi and colleagues, the broad expression of CD69 and its conserved ability to generate intracellular signals suggests a general role for the CD69 receptor in the biology of hematopoietic cells.

Original languageEnglish
Pages (from-to)479-483
Number of pages5
JournalTrends in Immunology
Issue number10
Publication statusPublished - Oct 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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