The Cellular and Molecular Basis of Translational Immunometabolism

Giuseppe Danilo Norata, Giuseppina Caligiuri, Triantafyllos Chavakis, Giuseppe Matarese, Mihai Gheorge Netea, Antonino Nicoletti, Luke A J O'Neill, Federica M. Marelli-Berg

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. A neglected aspect in the translation of immunometabolism is the critical connection between systemic and cellular metabolism. Here, we discuss the importance of understanding and manipulating the integration of systemic and immune cell metabolism through in-depth analysis of immune cell phenotype and function in human metabolic diseases and, in parallel, of the effects of conventional metabolic drugs on immune cell differentiation and function. We examine how the recent identification of selective metabolic programs operating in distinct immune cell subsets and functions has the potential to deliver tools for cell- and function-specific immunometabolic targeting.

Original languageEnglish
Article number3167
Pages (from-to)421-434
Number of pages14
JournalImmunity
Volume43
Issue number3
DOIs
Publication statusPublished - Sep 15 2015

Fingerprint

Metabolic Diseases
Energy Metabolism
Cell Differentiation
Phenotype
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology
  • Medicine(all)

Cite this

Norata, G. D., Caligiuri, G., Chavakis, T., Matarese, G., Netea, M. G., Nicoletti, A., ... Marelli-Berg, F. M. (2015). The Cellular and Molecular Basis of Translational Immunometabolism. Immunity, 43(3), 421-434. [3167]. https://doi.org/10.1016/j.immuni.2015.08.023

The Cellular and Molecular Basis of Translational Immunometabolism. / Norata, Giuseppe Danilo; Caligiuri, Giuseppina; Chavakis, Triantafyllos; Matarese, Giuseppe; Netea, Mihai Gheorge; Nicoletti, Antonino; O'Neill, Luke A J; Marelli-Berg, Federica M.

In: Immunity, Vol. 43, No. 3, 3167, 15.09.2015, p. 421-434.

Research output: Contribution to journalArticle

Norata, GD, Caligiuri, G, Chavakis, T, Matarese, G, Netea, MG, Nicoletti, A, O'Neill, LAJ & Marelli-Berg, FM 2015, 'The Cellular and Molecular Basis of Translational Immunometabolism', Immunity, vol. 43, no. 3, 3167, pp. 421-434. https://doi.org/10.1016/j.immuni.2015.08.023
Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A et al. The Cellular and Molecular Basis of Translational Immunometabolism. Immunity. 2015 Sep 15;43(3):421-434. 3167. https://doi.org/10.1016/j.immuni.2015.08.023
Norata, Giuseppe Danilo ; Caligiuri, Giuseppina ; Chavakis, Triantafyllos ; Matarese, Giuseppe ; Netea, Mihai Gheorge ; Nicoletti, Antonino ; O'Neill, Luke A J ; Marelli-Berg, Federica M. / The Cellular and Molecular Basis of Translational Immunometabolism. In: Immunity. 2015 ; Vol. 43, No. 3. pp. 421-434.
@article{95d60d3e5bcf4403b9c54bf98cdb1c40,
title = "The Cellular and Molecular Basis of Translational Immunometabolism",
abstract = "The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. A neglected aspect in the translation of immunometabolism is the critical connection between systemic and cellular metabolism. Here, we discuss the importance of understanding and manipulating the integration of systemic and immune cell metabolism through in-depth analysis of immune cell phenotype and function in human metabolic diseases and, in parallel, of the effects of conventional metabolic drugs on immune cell differentiation and function. We examine how the recent identification of selective metabolic programs operating in distinct immune cell subsets and functions has the potential to deliver tools for cell- and function-specific immunometabolic targeting.",
author = "Norata, {Giuseppe Danilo} and Giuseppina Caligiuri and Triantafyllos Chavakis and Giuseppe Matarese and Netea, {Mihai Gheorge} and Antonino Nicoletti and O'Neill, {Luke A J} and Marelli-Berg, {Federica M.}",
year = "2015",
month = "9",
day = "15",
doi = "10.1016/j.immuni.2015.08.023",
language = "English",
volume = "43",
pages = "421--434",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - The Cellular and Molecular Basis of Translational Immunometabolism

AU - Norata, Giuseppe Danilo

AU - Caligiuri, Giuseppina

AU - Chavakis, Triantafyllos

AU - Matarese, Giuseppe

AU - Netea, Mihai Gheorge

AU - Nicoletti, Antonino

AU - O'Neill, Luke A J

AU - Marelli-Berg, Federica M.

PY - 2015/9/15

Y1 - 2015/9/15

N2 - The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. A neglected aspect in the translation of immunometabolism is the critical connection between systemic and cellular metabolism. Here, we discuss the importance of understanding and manipulating the integration of systemic and immune cell metabolism through in-depth analysis of immune cell phenotype and function in human metabolic diseases and, in parallel, of the effects of conventional metabolic drugs on immune cell differentiation and function. We examine how the recent identification of selective metabolic programs operating in distinct immune cell subsets and functions has the potential to deliver tools for cell- and function-specific immunometabolic targeting.

AB - The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. A neglected aspect in the translation of immunometabolism is the critical connection between systemic and cellular metabolism. Here, we discuss the importance of understanding and manipulating the integration of systemic and immune cell metabolism through in-depth analysis of immune cell phenotype and function in human metabolic diseases and, in parallel, of the effects of conventional metabolic drugs on immune cell differentiation and function. We examine how the recent identification of selective metabolic programs operating in distinct immune cell subsets and functions has the potential to deliver tools for cell- and function-specific immunometabolic targeting.

UR - http://www.scopus.com/inward/record.url?scp=84941637376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941637376&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2015.08.023

DO - 10.1016/j.immuni.2015.08.023

M3 - Article

C2 - 26377896

AN - SCOPUS:84941637376

VL - 43

SP - 421

EP - 434

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 3

M1 - 3167

ER -