The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells

Silvia Gregori, Kevin S. Goudy, Maria Grazia Roncarolo

Research output: Contribution to journalArticlepeer-review

Abstract

The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellular and molecular mechanisms that humanTr1 cells use to control immune responses and induce tolerance. In this review we outline the well known and newly discovered regulatory properties of human Tr1 cells and provide an in-depth comparison of the known suppressor mechanisms of Tr1 cells with FOXP3+ Treg. We also highlight the role thatTr1 cells play in promoting and maintaining tolerance in autoimmunity, allergy, and transplantation.

Original languageEnglish
Article numberArticle 30
JournalFrontiers in Immunology
Volume3
Issue numberFEB
DOIs
Publication statusPublished - 2012

Keywords

  • Foxp3 T
  • IL-10
  • Immunotolerance
  • Tr1 cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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