Bone healing normally proceeds in successive stages, named the hematoma, granulation, repair blastema, cartilaginous callus and endochondral ossification. These different phases are strictly correlated. A failure in fracture healing is always the undesired result of an unsuccessful or altered cellular activity, due to a biological and/or mechanical events, occurring in bone repair. It has become increasingly clear the biochemical substances that participate in the local autocrine and paracrine regulation of bone healing, as well as the language through which the mechanical environment conveys some messages to the cells and how they can decode them. The latest knowledge of bone healing is synthesing and the possible mechanisms involved in the pathogenesis of pseudoarthrosis by altering the cellular basis of bone repair are presented. Some clinical involvements are also outlined.
|Translated title of the contribution||The cellular basis of pseudoarthrosis|
|Number of pages||5|
|Journal||Minerva Ortopedica e Traumatologica|
|Publication status||Published - 1996|
ASJC Scopus subject areas