The cellular origin of mantle cell lymphoma

Francesco Bertoni, Maurilio Ponzoni

Research output: Contribution to journalArticlepeer-review


Mantle cell lymphoma accounts for 5-10% of all non-Hodgkin's lymphomas and it has one the worst prognosis among all lymphomas. There is no therapy that can be considered as standard. Mantle cell lymphoma can show different "architectural" patterns as well different morphologic variants. Mantle cell lymphoma is believed to derive from marginal zone or peripheral blood memory B-cells. The immunophenotype of the neoplastic cells reflect the phenotype of a mature B-cell, even if mantle cell lymphoma cells are typically CD5+ and CD23-. Mantle cell lymphoma is characterized by the deregulated expression of cyclins D, mainly of cyclin D1, which is targeted by the t(11;14)(q13;q32) chromosomal translocation, the genetic hallmark of the disease. In this review will summarize the main morphologic and immunophenotypic features of the neoplastic cells, and the genetics and biology underlying the disease.{A textbox is presented}.

Original languageEnglish
Pages (from-to)1747-1753
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
Issue number10
Publication statusPublished - 2007


  • CCND1
  • Chromosomal translocation
  • Immunoglobulin
  • mTOR
  • NFKB
  • Somatic hypermutation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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