The central and peripheral hemodynamics of celiprolol

Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

The cardiovascular effects of celiprolol in healthy subjects and in those with cardiovascular disease and hypertension are reviewed. Unlike classic β-blockers, celiprolol does not depress cardiac contractility at rest while interfering to a lesser extent with cardiac function during exercise. Furthermore, celiprolol causes systemic vasodilatation, which, in hypertension, is mainly responsible for the blood pressure-reducing effects of the drug. Vasodilatation results from the reduction in vascular resistance of skeletal muscle tissues, but celiprolol also produces dilatation of vascular areas such as the kidney. This prevents a reduction in renal blood flow and consequently the salt and water retention associated with impaired perfusion. It is possible that such hemodynamic changes are dependent not on celiprolol's selective β1-receptor-blocking properties but on certain additional properties.

Original languageEnglish
Pages (from-to)1405-1411
Number of pages7
JournalAmerican Heart Journal
Volume116
Issue number5 PART 2
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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