The cerebellum in idiopathic cervical dystonia: A specific pattern of structural abnormalities?

Giuseppe Pontillo, Anna Castagna, Elena A. Vola, Antonella Macerollo, Silvio Peluso, Camilla Russo, Francesca Baglio, Fiore Manganelli, Arturo Brunetti, Sirio Cocozza, Marcello Esposito

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: In recent years, cerebellar abnormalities have gained increasing attention as possible physiopathological substratum of idiopathic cervical dystonia (ICD), but a consistent pattern of cerebellar structural modifications has not yet been established. We systematically investigated the presence of volumetric alterations of cerebellar gray (GM) and white matter (WM) in ICD patients, as well as their clinical relevance. Methods: In this two-centers prospective cross-sectional study, from May 2013 to December 2017, 27 patients with ICD and 27 age- and sex-comparable healthy controls underwent brain MRI including 3D T1-weighted sequences for volumetric analyses. Between-group differences in terms of gray matter and cerebellar peduncles volumes were investigated using both region of interest (ROI)-based and voxel-based approaches using the SUIT tool (SPM12), and significant volumetric changes were correlated with clinical impairment (as measured with the Tsui score) and presence of tremor. Results: ICD patients showed significant volumetric reduction of cerebellar GM in the anterior lobe and lobule VI, resulting from both ROI-based (p ≤ 0.009) and voxel-based (p ≤ 0.04) analyses, while small clusters of reduced WM volume were found in the right cerebellum and left midbrain (p = 0.04), along with reduced volume of the bilateral superior (p = 0.04) and middle (p = 0.03) cerebellar peduncles. Furthermore, higher middle cerebellar peduncles volume was associated with the presence of tremor (p = 0.04). Conclusion: Our data show evidence of a specific pattern of cerebellar structural abnormalities in ICD patients, with volume loss mainly involving cortical GM regions related to the somatotopic representation of the affected body parts and, to a lesser extent, cerebellar peduncles.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalParkinsonism and Related Disorders
Volume80
DOIs
Publication statusPublished - Nov 2020

Keywords

  • Cerebellar peduncles
  • Cerebellum
  • Idiopathic cervical dystonia
  • MRI
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'The cerebellum in idiopathic cervical dystonia: A specific pattern of structural abnormalities?'. Together they form a unique fingerprint.

Cite this