O desafio do tratamento da tuberculose extensivamente resistente em um hospital de referência no estado de São Paulo: Um relato de três casos

Translated title of the contribution: The challenge of managing extensively drug-resistant tuberculosis at a referral hospital in the state of São Paulo, Brazil: A report of three cases

Marcos Abdo Arbex, Hélio Ribeiro de Siqueira, Lia D’Ambrosio, Giovanni Battista Migliori

Research output: Contribution to journalArticlepeer-review

Abstract

Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test results, over a oneyear period. Treatment was based on the World Health Organization guidelines, with the inclusion of a new proposal for the use of a combination of antituberculosis drugs (imipenem and linezolid). In the cases studied, we show the challenge of creating an acceptable, effective treatment regimen including drugs that are more toxic, are more expensive, and are administered for longer periods. We also show that treatment costs are significantly higher for such patients, which could have an impact on health care systems, even after hospital discharge. We highlight the fact that in extreme cases, such as those reported here, hospitalization at a referral center seems to be the most effective strategy for providing appropriate treatment and increasing the chance of cure. In conclusion, health professionals and governments must make every effort to prevent cases of multidrug-resistant and extensively drug-resistant tuberculosis.

Translated title of the contributionThe challenge of managing extensively drug-resistant tuberculosis at a referral hospital in the state of São Paulo, Brazil: A report of three cases
Original languagePortuguese
Pages (from-to)554-559
Number of pages6
JournalJornal Brasileiro de Pneumologia
Volume41
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Antibiotics
  • Antitubercular
  • Antitubercular agents
  • Extensively drug-resistant tuberculosis
  • Multidrug-resistant
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint

Dive into the research topics of 'The challenge of managing extensively drug-resistant tuberculosis at a referral hospital in the state of São Paulo, Brazil: A report of three cases'. Together they form a unique fingerprint.

Cite this