The challenge of small lung nodules identified in CT screening

Can biomarkers assist diagnosis?

Research output: Contribution to journalArticle

Abstract

Various biomarkers have been developed as noninvasive tests to indicate the presence of lung cancer in asymptomatic persons, and in particular to provide evidence as to whether indeterminate lung nodules detected by screening are malignant. We performed an overview of the range of biomarkers reported in the literature and described those that can complement low-dose computed tomography screening. Several have promising sensitivity and specificity. However to our knowledge, only three techniques have reached the prospective screening phase (phase 4) of the five-phase biomarker development process. Two miRNA signatures (the miR-Test for serum and the miRNA signature classifier test for plasma) are being assessed in prospective screening trials, as is the EarlyCDT-Lung test based on autoantibodies. All will need to undergo prospective studies to determine their ability to improve outcomes before they can become an established adjunct to lung cancer control strategies.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalBiomarkers in Medicine
Volume10
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Biomarkers
Screening
MicroRNAs
Lung
Lung Neoplasms
Autoantibodies
Tomography
Prospective Studies
Sensitivity and Specificity
Classifiers
Serum
Plasmas

Keywords

  • Biomarkers
  • early diagnosis
  • low-dose computed tomography
  • lung cancer
  • screening

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

Cite this

The challenge of small lung nodules identified in CT screening : Can biomarkers assist diagnosis? / Veronesi, Giulia; Bianchi, Fabrizio; Infante, Maurizio; Alloisio, Marco.

In: Biomarkers in Medicine, Vol. 10, No. 2, 01.02.2016, p. 137-143.

Research output: Contribution to journalArticle

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