The challenges of clinical trials for adolescents and young adults with cancer

Andrea Ferrari, Michael Montello, Troy Budd, Archie Bleyer

Research output: Contribution to journalArticlepeer-review

Abstract

In the United States, Europe, and Australia, and probably all countries of the world, older adolescents and young adults with cancer are under-represented in clinical trials of therapies that could improve their outcome. Simultaneously, the survival and mortality rates in these patients have mirrored the clinical trial accrual pattern, with little improvement compared with younger and older patients. This suggests that the relative lack of participation of adolescent and young adult patients in clinical trials has lessened their chances for as good an outcome as that enjoyed by patients in other age groups. Thus, increased availability of and participation in clinical trials is of paramount important if the current deficits in outcome in young adults and older adolescents are to be eliminated. Regardless of whether there is a causal relationship, the impact of low clinical trial activity on furthering our scientific knowledge and management of cancer during adolescence and early adulthood is detrimental.

Original languageEnglish
Pages (from-to)1101-1104
Number of pages4
JournalPediatric Blood and Cancer
Volume50
Issue number5 SUPPL.
DOIs
Publication statusPublished - May 2008

Keywords

  • Clinical trials outcome

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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