The Characterization of Regulatory T-Cell Profiles in Alzheimer's Disease and Multiple Sclerosis

Fausta Ciccocioppo, Paola Lanuti, Laura Pierdomenico, Pasquale Simeone, Giuseppina Bologna, Eva Ercolino, Fabio Buttari, Roberta Fantozzi, Astrid Thomas, Marco Onofrj, Diego Centonze, Sebastiano Miscia, Marco Marchisio

Research output: Contribution to journalArticle

Abstract

Regulatory T Cells (Tregs) are a T-lymphocyte subset involved in the maintenance of immune peripheral tolerance. Despite evidence of the adaptive immune system's role in Alzheimer's Disease (AD), the involvement of Tregs is still not clear. We focused on the Flow-Cytometry analysis of the Treg frequencies and phenotypes in the AD. The aim of the study is to analyse similarities and differences in Tregs profile between Alzheimer's Disease and Multiple Sclerosis. Regulatory T Cells (CD4+/CD25high/CD127low-neg) were identified using an innovative Flow Cytometry method and subtyped as Resting (analysed CD45RApos/CD25dim), Activated (CD45RAneg/CD25bright) and Secreting (CD45RAneg/CD25dim) cells. Our data demonstrate a significant decrease in the total and Resting Tregs in AD patients when compared to healthy subjects. The percentage of the results of the Resting Tregs were also reduced in MS patients together with a parallel frequency increase of Activated Tregs. Our data suggest that altered Treg phenotypes observed in both diseases could play a role in the impairment of the Treg-mediated immunological tolerance, recalling a possible link between the two pathologies. Given that this study was conducted on a restricted population, if confirmed by a further and enlarged study, the implications of the autoimmune mechanisms in AD pathophysiology could open new immunotherapeutic perspectives based on Treg modulation.

Original languageEnglish
Pages (from-to)8788
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - Jun 19 2019

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    Ciccocioppo, F., Lanuti, P., Pierdomenico, L., Simeone, P., Bologna, G., Ercolino, E., Buttari, F., Fantozzi, R., Thomas, A., Onofrj, M., Centonze, D., Miscia, S., & Marchisio, M. (2019). The Characterization of Regulatory T-Cell Profiles in Alzheimer's Disease and Multiple Sclerosis. Scientific Reports, 9(1), 8788. https://doi.org/10.1038/s41598-019-45433-3