The chemical nature of the factor responsible for embryonic induction: An historical overview

Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

The discovery by Hans Spemann of the "organizer" tissue and its ability to induce the formation of the amphibian embryo's neural tube inspired leading embryologists to attempt to elucidate embryonic induction's underlying mechanisms. Since then several studies have described several developmental model system to better understand the role of specific signaling molecules, the interplay of different signals and tissue interactions in regulating tissue induction and patterning events. Different groups of workers set out to subject embryonic amphibian tissues and inductive adult organs to various extraction methods in the hope that the active agents could be isolated and chemically identified. In addition, a large number of well characterized chemical compounds were tested.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalOrganogenesis
Volume10
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Biochemistry
  • Embryology
  • Spemann organizer

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Transplantation
  • Biomedical Engineering
  • Medicine(all)

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