The chemical neuroanatomy of vagus nerve stimulation

Riccardo Ruffoli, Filippo S. Giorgi, Chiara Pizzanelli, Luigi Murri, Antonio Paparelli, Francesco Fornai

Research output: Contribution to journalArticle

Abstract

In this short overview a reappraisal of the anatomical connections of vagal afferents is reported. The manuscript moves from classic neuroanatomy to review details of vagus nerve anatomy which are now becoming more and more relevant for clinical outcomes (i.e. the therapeutic use of vagus nerve stimulation). In drawing such an updated odology of central vagal connections the anatomical basis subserving the neurochemical effects of vagal stimulation are addressed. In detail, apart from the thalamic projection of central vagal afferents, the monoaminergic systems appear to play a pivotal role. Stemming from the chemical neuroanatomy of monoamines such as serotonin and norepinephrine the widespread effects of vagal stimulation on cerebral cortical activity are better elucidated. This refers both to the antiepileptic effects and most recently to the beneficial effects of vagal stimulation in mood and cognitive disorders.

Original languageEnglish
Pages (from-to)288-296
Number of pages9
JournalJournal of Chemical Neuroanatomy
Volume42
Issue number4
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Vagus Nerve Stimulation
Neuroanatomy
Vagus Nerve
Manuscripts
Therapeutic Uses
Mood Disorders
Anticonvulsants
Serotonin
Anatomy
Norepinephrine

Keywords

  • Locus coeruleus
  • Monoamine
  • Norepinephrine
  • Raphe nuclei
  • Serotonin
  • Vagus nerve

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Ruffoli, R., Giorgi, F. S., Pizzanelli, C., Murri, L., Paparelli, A., & Fornai, F. (2011). The chemical neuroanatomy of vagus nerve stimulation. Journal of Chemical Neuroanatomy, 42(4), 288-296. https://doi.org/10.1016/j.jchemneu.2010.12.002

The chemical neuroanatomy of vagus nerve stimulation. / Ruffoli, Riccardo; Giorgi, Filippo S.; Pizzanelli, Chiara; Murri, Luigi; Paparelli, Antonio; Fornai, Francesco.

In: Journal of Chemical Neuroanatomy, Vol. 42, No. 4, 12.2011, p. 288-296.

Research output: Contribution to journalArticle

Ruffoli, R, Giorgi, FS, Pizzanelli, C, Murri, L, Paparelli, A & Fornai, F 2011, 'The chemical neuroanatomy of vagus nerve stimulation', Journal of Chemical Neuroanatomy, vol. 42, no. 4, pp. 288-296. https://doi.org/10.1016/j.jchemneu.2010.12.002
Ruffoli, Riccardo ; Giorgi, Filippo S. ; Pizzanelli, Chiara ; Murri, Luigi ; Paparelli, Antonio ; Fornai, Francesco. / The chemical neuroanatomy of vagus nerve stimulation. In: Journal of Chemical Neuroanatomy. 2011 ; Vol. 42, No. 4. pp. 288-296.
@article{fe76ca56ec044cbeb545b187006b87f9,
title = "The chemical neuroanatomy of vagus nerve stimulation",
abstract = "In this short overview a reappraisal of the anatomical connections of vagal afferents is reported. The manuscript moves from classic neuroanatomy to review details of vagus nerve anatomy which are now becoming more and more relevant for clinical outcomes (i.e. the therapeutic use of vagus nerve stimulation). In drawing such an updated odology of central vagal connections the anatomical basis subserving the neurochemical effects of vagal stimulation are addressed. In detail, apart from the thalamic projection of central vagal afferents, the monoaminergic systems appear to play a pivotal role. Stemming from the chemical neuroanatomy of monoamines such as serotonin and norepinephrine the widespread effects of vagal stimulation on cerebral cortical activity are better elucidated. This refers both to the antiepileptic effects and most recently to the beneficial effects of vagal stimulation in mood and cognitive disorders.",
keywords = "Locus coeruleus, Monoamine, Norepinephrine, Raphe nuclei, Serotonin, Vagus nerve",
author = "Riccardo Ruffoli and Giorgi, {Filippo S.} and Chiara Pizzanelli and Luigi Murri and Antonio Paparelli and Francesco Fornai",
year = "2011",
month = "12",
doi = "10.1016/j.jchemneu.2010.12.002",
language = "English",
volume = "42",
pages = "288--296",
journal = "Journal of Chemical Neuroanatomy",
issn = "0891-0618",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - The chemical neuroanatomy of vagus nerve stimulation

AU - Ruffoli, Riccardo

AU - Giorgi, Filippo S.

AU - Pizzanelli, Chiara

AU - Murri, Luigi

AU - Paparelli, Antonio

AU - Fornai, Francesco

PY - 2011/12

Y1 - 2011/12

N2 - In this short overview a reappraisal of the anatomical connections of vagal afferents is reported. The manuscript moves from classic neuroanatomy to review details of vagus nerve anatomy which are now becoming more and more relevant for clinical outcomes (i.e. the therapeutic use of vagus nerve stimulation). In drawing such an updated odology of central vagal connections the anatomical basis subserving the neurochemical effects of vagal stimulation are addressed. In detail, apart from the thalamic projection of central vagal afferents, the monoaminergic systems appear to play a pivotal role. Stemming from the chemical neuroanatomy of monoamines such as serotonin and norepinephrine the widespread effects of vagal stimulation on cerebral cortical activity are better elucidated. This refers both to the antiepileptic effects and most recently to the beneficial effects of vagal stimulation in mood and cognitive disorders.

AB - In this short overview a reappraisal of the anatomical connections of vagal afferents is reported. The manuscript moves from classic neuroanatomy to review details of vagus nerve anatomy which are now becoming more and more relevant for clinical outcomes (i.e. the therapeutic use of vagus nerve stimulation). In drawing such an updated odology of central vagal connections the anatomical basis subserving the neurochemical effects of vagal stimulation are addressed. In detail, apart from the thalamic projection of central vagal afferents, the monoaminergic systems appear to play a pivotal role. Stemming from the chemical neuroanatomy of monoamines such as serotonin and norepinephrine the widespread effects of vagal stimulation on cerebral cortical activity are better elucidated. This refers both to the antiepileptic effects and most recently to the beneficial effects of vagal stimulation in mood and cognitive disorders.

KW - Locus coeruleus

KW - Monoamine

KW - Norepinephrine

KW - Raphe nuclei

KW - Serotonin

KW - Vagus nerve

UR - http://www.scopus.com/inward/record.url?scp=79959371015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959371015&partnerID=8YFLogxK

U2 - 10.1016/j.jchemneu.2010.12.002

DO - 10.1016/j.jchemneu.2010.12.002

M3 - Article

C2 - 21167932

AN - SCOPUS:79959371015

VL - 42

SP - 288

EP - 296

JO - Journal of Chemical Neuroanatomy

JF - Journal of Chemical Neuroanatomy

SN - 0891-0618

IS - 4

ER -