The chemokine system in cancer biology and therapy

Research output: Contribution to journalArticle

236 Citations (Scopus)

Abstract

Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors are downstream of genetic events that cause neoplastic transformation and are components of chronic inflammatory conditions, which predispose to cancer. Components of the chemokine system affect in a cell autonomous or non-autonomous way multiple pathways of tumor progression, including: leukocyte recruitment and function; cellular senescence; tumor cell proliferation and survival; invasion and metastasis. Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.

Original languageEnglish
Pages (from-to)27-39
Number of pages13
JournalCytokine and Growth Factor Reviews
Volume21
Issue number1
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Chemokines
Tumors
Neoplasms
Chemokine Receptors
Cell Aging
Cell proliferation
Therapeutics
Cell Survival
Leukocytes
Cell Proliferation
Neoplasm Metastasis
Inflammation

Keywords

  • Cancer
  • Chemokine
  • Chemokine Receptor
  • Inflammation

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The chemokine system in cancer biology and therapy. / Mantovani, Alberto; Savino, Benedetta; Locati, Massimo; Zammataro, Luca; Allavena, Paola; Bonecchi, Raffaella.

In: Cytokine and Growth Factor Reviews, Vol. 21, No. 1, 02.2010, p. 27-39.

Research output: Contribution to journalArticle

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