The chick embryo chorioallantoic membrane as a model for in vivo research on angiogenesis

Domenico Ribatti, Angelo Vacca, Luisa Roncali, Franco Dammacco

Research output: Contribution to journalArticlepeer-review

Abstract

The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane that is commonly used in vivo to study both new vessel formation and its inhibition in response to tissues, cells, or soluble factors. Quantitative or semiquantitative methods may be used to evaluate the amount of angiogenesis and anti-angiogenesis. Thanks to the CAM system, angiogenesis could be investigated in association with normal, inflammatory and tumor tissues, and soluble factors inducing angiogenic or anti-angiogenic effects could be identified. Rabbit cornea provides an alternative in vivo system, but CAM appears to be easier to handle and less expensive. Moreover, CAM can be used with very few limitations.

Original languageEnglish
Pages (from-to)1189-1197
Number of pages9
JournalInternational Journal of Developmental Biology
Volume40
Issue number6
Publication statusPublished - 1996

Keywords

  • angiogenesis
  • anti-angiogenesis
  • chick embryo
  • chorioallantoic membrane

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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