Abstract
The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane that is commonly used in vivo to study both new vessel formation and its inhibition in response to tissues, cells, or soluble factors. Quantitative or semiquantitative methods may be used to evaluate the amount of angiogenesis and anti-angiogenesis. Thanks to the CAM system, angiogenesis could be investigated in association with normal, inflammatory and tumor tissues, and soluble factors inducing angiogenic or anti-angiogenic effects could be identified. Rabbit cornea provides an alternative in vivo system, but CAM appears to be easier to handle and less expensive. Moreover, CAM can be used with very few limitations.
Original language | English |
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Pages (from-to) | 1189-1197 |
Number of pages | 9 |
Journal | International Journal of Developmental Biology |
Volume | 40 |
Issue number | 6 |
Publication status | Published - 1996 |
Keywords
- angiogenesis
- anti-angiogenesis
- chick embryo
- chorioallantoic membrane
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology