Abstract
Anti-angiogenesis, i.e. inhibition of blood vessel growth, is being investigated as a way to prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological inhibition interferes with the angiogenic cascade or the immature neovasculature with synthetic or semi-synthetic substances, endogenous inhibitors or biological antagonists. The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane commonly used in vivo to study both new vessel formation and its inhibition in response to tissues, cells, or soluble factors. Angiogenesis or anti-angiogenesis is evaluated quantitatively or semiquantitatively. The fields of application of CAM in the study of anti-angiogenesis, including our personal experience, are illustrated in this paper.
| Original language | English |
|---|---|
| Pages (from-to) | 73-82 |
| Number of pages | 10 |
| Journal | Current Pharmaceutical Biotechnology |
| Volume | 1 |
| Issue number | 1 |
| Publication status | Published - Jul 2000 |
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ASJC Scopus subject areas
- Pharmaceutical Science
- Molecular Medicine
- Biotechnology
Cite this
The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesis. / Ribatti, D.; Vacca, A.; Roncali, L.; Dammacco, F.
In: Current Pharmaceutical Biotechnology, Vol. 1, No. 1, 07.2000, p. 73-82.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesis.
AU - Ribatti, D.
AU - Vacca, A.
AU - Roncali, L.
AU - Dammacco, F.
PY - 2000/7
Y1 - 2000/7
N2 - Anti-angiogenesis, i.e. inhibition of blood vessel growth, is being investigated as a way to prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological inhibition interferes with the angiogenic cascade or the immature neovasculature with synthetic or semi-synthetic substances, endogenous inhibitors or biological antagonists. The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane commonly used in vivo to study both new vessel formation and its inhibition in response to tissues, cells, or soluble factors. Angiogenesis or anti-angiogenesis is evaluated quantitatively or semiquantitatively. The fields of application of CAM in the study of anti-angiogenesis, including our personal experience, are illustrated in this paper.
AB - Anti-angiogenesis, i.e. inhibition of blood vessel growth, is being investigated as a way to prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological inhibition interferes with the angiogenic cascade or the immature neovasculature with synthetic or semi-synthetic substances, endogenous inhibitors or biological antagonists. The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane commonly used in vivo to study both new vessel formation and its inhibition in response to tissues, cells, or soluble factors. Angiogenesis or anti-angiogenesis is evaluated quantitatively or semiquantitatively. The fields of application of CAM in the study of anti-angiogenesis, including our personal experience, are illustrated in this paper.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034232194&partnerID=8YFLogxK
M3 - Article
C2 - 11467363
AN - SCOPUS:0034232194
VL - 1
SP - 73
EP - 82
JO - Current Pharmaceutical Biotechnology
JF - Current Pharmaceutical Biotechnology
SN - 1389-2010
IS - 1
ER -