The chick embryo chorioallantoic membrane as an in vivo assay to study antiangiogenesis

Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

Antiangiogenesis, e.g., inhibition of blood vessel growth, is being investigated as a way to prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological inhibition interferes with the angiogenic cascade or the immature neovasculature with synthetic or semi-synthetic substances, endogenous inhibitors or biological antagonists. The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane, which serves as a gas exchange surface and its function is supported by a dense capillary network. Because its extensive vascularization and easy accessibility, CAM has been used to study morphofunctional aspects of the angiogenesis process in vivo and to study the efficacy and mechanism of action of pro- and anti-angiogenic molecules. The fields of application of CAM in the study of antiangiogenesis, including our personal experience, are illustrated in this review article.

Original languageEnglish
Pages (from-to)482-513
Number of pages32
JournalPharmaceuticals
Volume3
Issue number3
DOIs
Publication statusPublished - 2010

Keywords

  • Antiangiogenesis
  • Chorioallantoic membrane
  • Tumor progression

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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