The chicken adenovirus Gam1 protein, an inhibitor of the sumoylation pathway, partially complements ICP0-null mutant herpes simplex virus 1

Roger D. Everett, Susanna Chiocca, Anne Orr

Research output: Contribution to journalArticle


Herpes simplex virus 1 (HSV-1) regulatory protein ICP0 stimulates efficient infection via its E3 ubiquitin ligase activity that causes degradation of several cellular proteins, some of which are sumoylated. Chicken adenovirus Gam1 protein also interferes with the sumoylation pathway, and both proteins disrupt promyelocytic leukemia protein (PML) nuclear bodies (NBs). We report that Gam1 increases the infection efficiency of ICP0-null mutant HSV-1 by approximately 100-fold, thus strengthening the hypothesis that PML NB- and sumoylation-related mechanisms are important factors in the control of HSV-1 infection.

Original languageEnglish
Pages (from-to)5873-5876
Number of pages4
JournalJournal of Virology
Issue number10
Publication statusPublished - 2014


ASJC Scopus subject areas

  • Immunology
  • Virology

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