The chicken adenovirus Gam1 protein, an inhibitor of the sumoylation pathway, partially complements ICP0-null mutant herpes simplex virus 1

Roger D. Everett, Susanna Chiocca, Anne Orr

Research output: Contribution to journalArticle

Abstract

Herpes simplex virus 1 (HSV-1) regulatory protein ICP0 stimulates efficient infection via its E3 ubiquitin ligase activity that causes degradation of several cellular proteins, some of which are sumoylated. Chicken adenovirus Gam1 protein also interferes with the sumoylation pathway, and both proteins disrupt promyelocytic leukemia protein (PML) nuclear bodies (NBs). We report that Gam1 increases the infection efficiency of ICP0-null mutant HSV-1 by approximately 100-fold, thus strengthening the hypothesis that PML NB- and sumoylation-related mechanisms are important factors in the control of HSV-1 infection.

Original languageEnglish
Pages (from-to)5873-5876
Number of pages4
JournalJournal of Virology
Volume88
Issue number10
DOIs
Publication statusPublished - 2014

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ASJC Scopus subject areas

  • Immunology
  • Virology

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