The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND): Test development and reliability

A. M. Glanzman, E. Mazzone, M. Main, M. Pelliccioni, J. Wood, K. J. Swoboda, C. Scott, M. Pane, S. Messina, E. Bertini, E. Mercuri, R. S. Finkel

Research output: Contribution to journalArticle

Abstract

The motor skills of patients with spinal muscular atrophy, type I (SMA-I) are very limited. It is difficult to quantify the motor abilities of these patients and as a result there is currently no validated measure of motor function that can be utilized as an outcome measure in clinical trials of SMA-I. We have developed the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (" CHOP INTEND" ) to evaluate the motor skills of patients with SMA-I. The test was developed following the evaluation of 26 infants with SMA-I mean age 11.5. months (1.4-37.9. months) with the Test of Infant Motor Performance and The Children's Hospital of Philadelphia Test of Strength in SMA, a newly devised motor assessment for SMA. Items for the CHOP INTEND were selected by an expert panel based on item mean and standard deviation, item frequency distribution, and Chronbach's alpha. Intra-rater reliability of the resulting test was established by test-retest of 9 infants with SMA-I over a 2. month period; Intraclass correlation coefficient (ICC) (3,1) = 0.96. Interrater reliability was by video analysis of a mixed group of infants with neuromuscular disease by 4 evaluators; ICC (3,4) = 0.98 and in a group of 8 typically developing infants by 5 evaluators ICC (3,5) = 0.93. The face validity of the CHOP INTEND is supported by the use of an expert panel in item selection; however, further validation is needed. The CHOP INTEND is a reliable measure of motor skills in patients with SMA-I and neuromuscular disorders presenting in infancy.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalNeuromuscular Disorders
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Keywords

  • Assessment
  • Floppy infant
  • Hypotonia
  • Hypotonic
  • Infant
  • Motor assessment
  • Motor scale
  • Neuromuscular disorder
  • Outcome measure
  • SMA
  • SMA type I
  • Spinal muscular atrophy
  • Weakness

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)
  • Neurology

Cite this

Glanzman, A. M., Mazzone, E., Main, M., Pelliccioni, M., Wood, J., Swoboda, K. J., Scott, C., Pane, M., Messina, S., Bertini, E., Mercuri, E., & Finkel, R. S. (2010). The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND): Test development and reliability. Neuromuscular Disorders, 20(3), 155-161. https://doi.org/10.1016/j.nmd.2009.11.014