The cholinergic component in the reflex vasodilatation elicited by stimulation of the depressor nerves in the rabbit

M. Chiariello, M. Condorelli, L. de Caprio, F. Rengo, L. Saccà, B. Trimarco

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of the stimulation of the cephalic endings of the depressor nerve on the resistance in the perfused hindlimb were studied in the rabbit. The vasodilatation thus elicited in the perfused hindlimb was reduced either by administration of guanethidine or by sympathectomy and abolished by subsequent treatment with atropine. These data confirm the existence of two components in the genesis of the reflex vasodilatation: a passive component, due to the inhibition of sympathetic discharge, and an active component which in the rabbit is cholinergic in nature.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalBritish Journal of Pharmacology
Volume57
Issue number3
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Pharmacology

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