The circadian clock and the hypoxic response pathway in kidney cancer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The most frequent malignant tumor of the kidney in adults is represented by renal cell carcinoma characterized by high lethality related to presence of metastatic disease at the time of diagnosis. The main characteristic molecular feature of most sporadic renal cell carcinomas is the mutation of the tumor suppressor gene encoding the von Hippel-Lindau protein, with alteration of regulated pathways and activation of hypoxia-inducible transcription factors. Hypoxia-inducible transcription factors are transcriptional regulators of genes controlling mammalian oxygen homeostasis, energy metabolism, neovascularisation, internal pH, cell survival, and migration and are considered powerful promoters of tumor growth. Tight interrelationships have been evidenced between hypoxic response pathway and circadian pathway. Severe deregulation of genes involved in the circadian clock circuitry and response to hypoxia has been found in patients affected by kidney cancer, influencing the process of carcinogenesis, as well as disease progression and outcome. The study of alterations of clock gene expression and hypoxia correlated pathway in kidney cancer may promote the comprehension of pathophysiological mechanisms involved in renal cell carcinoma onset and evolution and may help to exploit more effective therapeutic approaches.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalTumor Biology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Circadian Clocks
Kidney Neoplasms
Renal Cell Carcinoma
Transcription Factors
Regulator Genes
Tumor Suppressor Genes
Carcinogens
Energy Metabolism
Cell Movement
Disease Progression
Cell Survival
Carcinogenesis
Homeostasis
Oxygen
Kidney
Gene Expression
Mutation
Hypoxia
Growth
Genes

Keywords

  • Cancer
  • Circadian
  • Clock gene
  • Hypoxia
  • Kidney
  • Rhythm

ASJC Scopus subject areas

  • Cancer Research

Cite this

The circadian clock and the hypoxic response pathway in kidney cancer. / Mazzoccoli, Gianluigi; De Cata, Angelo; Piepoli, Ada; Vinciguerra, Manlio.

In: Tumor Biology, Vol. 35, No. 1, 01.2014, p. 1-7.

Research output: Contribution to journalArticle

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