The circadian rhythm of body core temperature (CRT) is normal in patient with congenital generalized anhidrosis

Sabina Cevoli, Giulia Pierangeli, Fabiola Magnifico, Giuseppe Bonavina, Giorgio Barletta, Carmen Candela, Pasquale Montagna, Pietro Cortelli

Research output: Contribution to journalArticlepeer-review


The temperature of the human body is not constant during the day, and is related to a double modulation of both homeostatic and circadian processes. The circadian rhythm of body core temperature (CRT) is known to depend on the central mechanism involved in thermoregulatory variations. The role of sweating in the nocturnal fall of body core temperature (BcT) is not clear. We evaluated the CRT in a 45-year-old female with a lack of sweating since birth because of congenital generalized anhidrosis. She referred episodes of heat intolerance when ambient temperature was around 35°C. Skin biopsies of both forearms and left axilla revealed atrophy and morphologic changes of eccrine glands. Neurological examination, nerve conduction studies, sympathetic skin response and cardiovascular reflex tests were normal. The study of CRT was performed by monitoring rectal temperature continuously in controlled conditions (ambient temperature 24 ± 1°C and humidity 40-50% in a light-dark schedule). The rhythmometric analysis showed normal 24-hour fluctuations. This case represents an "experiment of nature" demonstrating that the physiological nocturnal fall of BcT is independent of sweating.

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalClinical Autonomic Research
Issue number3
Publication statusPublished - 2002


  • Anhidrosis
  • Body core temperature
  • Circadian rhythm

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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