The circulating endothelial cell in cancer: Towards marker and target identification

Inis Martin-Padura, F. Bertolini

Research output: Contribution to journalArticle

Abstract

Circulating endothelial cell (CEC) and progenitor (CEP) number and viability are modulated in various pathological conditions including cancer. There is increasing evidence showing that CEC and CEP play a role in cancer progression and metastasis in different animal models. At the clinical level, emerging data support that CEC and CEP kinetics and viability might predict the efficacy on anticancer drug combinations that include antiangiogenic agents. On the basis of these observations, CEC and CEP measurements have attractive potential diagnostic and therapeutic applications for malignant diseases.

Original languageEnglish
Pages (from-to)3780-3789
Number of pages10
JournalCurrent Pharmaceutical Design
Volume14
Issue number36
DOIs
Publication statusPublished - 2008

Keywords

  • Angiogenesis
  • Cancer
  • Endothelial cells
  • Endothelial progenitors
  • Tumor
  • Vasculogenesis

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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