The Circulating Level of Soluble Receptor for Advanced Glycation End Products Displays Different Patterns in Ulcerative Colitis and Crohn’s Disease: A Cross-Sectional Study

Rachele Ciccocioppo, Venerina Imbesi, Elena Betti, Vincenzo Boccaccio, Peter Kruzliak, Alessandra Gallia, Giuseppina Cristina Cangemi, Gabriella Carnevale Maffe, Alessandro Vanoli, Serena Merante, Mara De Amici, Colomba Falcone, Catherine Klersy, Gino Roberto Corazza

Research output: Contribution to journalArticle

Abstract

Background: RAGE is a transmembrane receptor expressed on immune and endothelial cells, whose binding with its ligands, the S100 calgranulins, leads to chronic inflammation. Conversely, its soluble form (sRAGE) plays a protective role by acting as a decoy. We carried out a cross-sectional analysis of the sRAGE and S100A12 serum levels in patients with Crohn’s disease (CD) and ulcerative colitis (UC) and searched for a correlation with clinical and biological markers of activity. Methods: We enrolled 60 CD, 67 UC patients, and 66 controls (all adults). Disease activity was scored through the clinical, endoscopic, and histologic indexes of severity, whilst disease location and behaviour were assessed according to the Montreal classification. In all cases, the levels of serum sRAGE, S100A12, C-reactive protein, and faecal calprotectin were measured. Results: sRAGE levels were significantly lower in UC, both active and inactive, than in controls and CD (817.35, range 437.3–1449; 1211, range 843.7–1618; 1207.5, range 743.15–1875.75; P 

Original languageEnglish
Pages (from-to)2327-2337
Number of pages11
JournalDigestive Diseases and Sciences
Volume60
Issue number8
DOIs
Publication statusPublished - Aug 23 2015

Keywords

  • Biomarker
  • Crohn’s disease
  • Disease activity
  • Receptor for the advanced glycation end products
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology
  • Medicine(all)

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