The circulating levels of TRAIL are extremely low after delivery but rapidly recover in both mothers and newborns

Giorgio Zauli, Lorenzo Monasta, Liza Vecchi Brumatti, Chiara Agnoletto, Patrizia Volpi, Paola Secchiero

Research output: Contribution to journalArticle

Abstract

TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1. h (time 1) and 2-3. days (time 2) after delivery in a group of healthy women (n= 17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3. pg/ml median; 41.2. ±. 15.9 mean. ±. SD) to time 2 (71.6. pg/ml median; 73.8. ±. 27.8 mean. ±. SD). Similarly, circulating TRAIL levels were extremely low in the plasma of newborns (n= 41) within the first 24. h after partum (time 1; 27.5. pg/ml, median; 31.5. ±. 15.8 means. ±. SD), showing a significant increase 2-3. days after partum (time 2; 68.4. pg/ml, median; 75.1. ±. 36.7 mean. ±. SD). It is also noteworthy that the highest levels of plasma TRAIL were observed in newborns with the following characteristics: (i) born at later gestational age, (ii) Apgar score >9, (iii) higher birth weight, (iv) born through vaginal partum. In conclusion, we have demonstrated for the first time that the levels of circulating TRAIL are markedly low in both mothers and children after delivery, rapidly rising thereafter. Moreover, the highest levels of TRAIL are observed in newborns with the best clinical parameters.

Original languageEnglish
Pages (from-to)51-53
Number of pages3
JournalCytokine
Volume64
Issue number1
DOIs
Publication statusPublished - Oct 2013

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Keywords

  • Apgar
  • Delivery
  • Mothers, newborns
  • TRAIL

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

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