I Classici della Nefrologia Italiana. ''Gli ormoni nella fisiologia e nella patologia del rene'' di Silvano Lamperi (1922-2008) e Rodolfo Cheli (1928-1997).

Translated title of the contribution: [The classics of Italian nephrology: ''Hormones in renal physiology and renal pathology'' by Silvano Lamperi (1922-2008) e Rodolfo Cheli (1928-1997)].

G. B. Fogazzi

Research output: Contribution to journalArticle

Abstract

This monograph, published in 1955, describes the effects that cortisone, desoxycorticosterone, adrenocorticotropic hormone, growth hormone, and testosterone have on renal function, renal metabolism and renal enzymatic activity. The two main chapters of the book describe the experimental results obtained by the authors with the administration of the above-mentioned hormones to rats in terms of renal morphology and function both in basal conditions and after the injection of nephroptoxic substances. Interestingly, the effects on function were evaluated by the measurement of the consumption of oxygen by kidney sections incubated with hormones in different experimental conditions. The results demonstrated that both cortisone and adrenocorticosterone could have a protective effect on kidney damage, which could be used for clinical purposes. Today, the monograph by Lamperi and Cheli is interesting because it shows that advanced experimental research was carried out in Italy in the early 1950s. Moreover, it represents an early attempt to the application of experimental results to the clinic.

Original languageItalian
Pages (from-to)250-254
Number of pages5
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume26
Issue number2
Publication statusPublished - Mar 2009

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Nephrology
Hormones
Pathology
Kidney
Cortisone
Desoxycorticosterone
Oxygen Consumption
Adrenocorticotropic Hormone
Italy
Growth Hormone
Testosterone
Injections
Research

ASJC Scopus subject areas

  • Nephrology

Cite this

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abstract = "This monograph, published in 1955, describes the effects that cortisone, desoxycorticosterone, adrenocorticotropic hormone, growth hormone, and testosterone have on renal function, renal metabolism and renal enzymatic activity. The two main chapters of the book describe the experimental results obtained by the authors with the administration of the above-mentioned hormones to rats in terms of renal morphology and function both in basal conditions and after the injection of nephroptoxic substances. Interestingly, the effects on function were evaluated by the measurement of the consumption of oxygen by kidney sections incubated with hormones in different experimental conditions. The results demonstrated that both cortisone and adrenocorticosterone could have a protective effect on kidney damage, which could be used for clinical purposes. Today, the monograph by Lamperi and Cheli is interesting because it shows that advanced experimental research was carried out in Italy in the early 1950s. Moreover, it represents an early attempt to the application of experimental results to the clinic.",
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