The Classification of Lymphomas: Updating the WHO Classification

Elias Campo, Stefano A. Pileri

Research output: Chapter in Book/Report/Conference proceedingChapter


The classification of lymphoid neoplasms of the World Health Organization (WHO) is based on two major principles: stratification of the neoplasms according to their cell lineage (B or T/NK) and the definition of non-overlapping distinct diseases that are clinically relevant. The identification of these entities is based on a combination of morphology, immunophenotype, genetic and molecular features and clinical manifestations. The relevance of these criteria is variable in different entities but the diagnosis always requires a multidisciplinary approach. The classification constitutes a reference framework for clinical practice and for the investigation of these neoplasms in all perspectives. New advances in the immunological, genetic and molecular alterationsof these neoplasms have expanded our understanding refining the diagnostic criteria, identifying new clinical and biological subtypes and providing solid basis for the development of new therapeutic strategies. This chapter reviews the basis of the classification and the diagnostic criteria required in each entity and also incorporates relevant new information generated since the publication of the classification, particularly in the field of molecular and genetic alterations, that may contribute to the diagnosis and new therapeutic perspectives.

Original languageEnglish
Title of host publicationPostgraduate Haematology: Seventh Edition
PublisherWiley Blackwell
Number of pages26
ISBN (Electronic)9781118853771
ISBN (Print)9781118854327
Publication statusPublished - Nov 6 2015


  • B-cell lymphoma
  • Hodgkin lymphoma
  • Lymphoid neoplasms
  • T/NK-cell lymphoma
  • WHO classification

ASJC Scopus subject areas

  • Medicine(all)


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