The Classification of Lymphomas: Updating the WHO Classification

Elias Campo, Stefano A. Pileri

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The classification of lymphoid neoplasms of the World Health Organization (WHO) is based on two major principles: stratification of the neoplasms according to their cell lineage (B or T/NK) and the definition of non-overlapping distinct diseases that are clinically relevant. The identification of these entities is based on a combination of morphology, immunophenotype, genetic and molecular features and clinical manifestations. The relevance of these criteria is variable in different entities but the diagnosis always requires a multidisciplinary approach. The classification constitutes a reference framework for clinical practice and for the investigation of these neoplasms in all perspectives. New advances in the immunological, genetic and molecular alterationsof these neoplasms have expanded our understanding refining the diagnostic criteria, identifying new clinical and biological subtypes and providing solid basis for the development of new therapeutic strategies. This chapter reviews the basis of the classification and the diagnostic criteria required in each entity and also incorporates relevant new information generated since the publication of the classification, particularly in the field of molecular and genetic alterations, that may contribute to the diagnosis and new therapeutic perspectives.

Original languageEnglish
Title of host publicationPostgraduate Haematology: Seventh Edition
PublisherWiley Blackwell
Pages575-600
Number of pages26
ISBN (Electronic)9781118853771
ISBN (Print)9781118854327
DOIs
Publication statusPublished - Nov 6 2015

Fingerprint

Lymphoma
Molecular Biology
Neoplasms
Cell Lineage
Publications
Therapeutics

Keywords

  • B-cell lymphoma
  • Hodgkin lymphoma
  • Lymphoid neoplasms
  • T/NK-cell lymphoma
  • WHO classification

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Campo, E., & Pileri, S. A. (2015). The Classification of Lymphomas: Updating the WHO Classification. In Postgraduate Haematology: Seventh Edition (pp. 575-600). Wiley Blackwell. https://doi.org/10.1002/9781118853771.ch31

The Classification of Lymphomas : Updating the WHO Classification. / Campo, Elias; Pileri, Stefano A.

Postgraduate Haematology: Seventh Edition. Wiley Blackwell, 2015. p. 575-600.

Research output: Chapter in Book/Report/Conference proceedingChapter

Campo, E & Pileri, SA 2015, The Classification of Lymphomas: Updating the WHO Classification. in Postgraduate Haematology: Seventh Edition. Wiley Blackwell, pp. 575-600. https://doi.org/10.1002/9781118853771.ch31
Campo E, Pileri SA. The Classification of Lymphomas: Updating the WHO Classification. In Postgraduate Haematology: Seventh Edition. Wiley Blackwell. 2015. p. 575-600 https://doi.org/10.1002/9781118853771.ch31
Campo, Elias ; Pileri, Stefano A. / The Classification of Lymphomas : Updating the WHO Classification. Postgraduate Haematology: Seventh Edition. Wiley Blackwell, 2015. pp. 575-600
@inbook{4406e12f66f841aeb93336fb358d15dc,
title = "The Classification of Lymphomas: Updating the WHO Classification",
abstract = "The classification of lymphoid neoplasms of the World Health Organization (WHO) is based on two major principles: stratification of the neoplasms according to their cell lineage (B or T/NK) and the definition of non-overlapping distinct diseases that are clinically relevant. The identification of these entities is based on a combination of morphology, immunophenotype, genetic and molecular features and clinical manifestations. The relevance of these criteria is variable in different entities but the diagnosis always requires a multidisciplinary approach. The classification constitutes a reference framework for clinical practice and for the investigation of these neoplasms in all perspectives. New advances in the immunological, genetic and molecular alterationsof these neoplasms have expanded our understanding refining the diagnostic criteria, identifying new clinical and biological subtypes and providing solid basis for the development of new therapeutic strategies. This chapter reviews the basis of the classification and the diagnostic criteria required in each entity and also incorporates relevant new information generated since the publication of the classification, particularly in the field of molecular and genetic alterations, that may contribute to the diagnosis and new therapeutic perspectives.",
keywords = "B-cell lymphoma, Hodgkin lymphoma, Lymphoid neoplasms, T/NK-cell lymphoma, WHO classification",
author = "Elias Campo and Pileri, {Stefano A.}",
year = "2015",
month = "11",
day = "6",
doi = "10.1002/9781118853771.ch31",
language = "English",
isbn = "9781118854327",
pages = "575--600",
booktitle = "Postgraduate Haematology: Seventh Edition",
publisher = "Wiley Blackwell",

}

TY - CHAP

T1 - The Classification of Lymphomas

T2 - Updating the WHO Classification

AU - Campo, Elias

AU - Pileri, Stefano A.

PY - 2015/11/6

Y1 - 2015/11/6

N2 - The classification of lymphoid neoplasms of the World Health Organization (WHO) is based on two major principles: stratification of the neoplasms according to their cell lineage (B or T/NK) and the definition of non-overlapping distinct diseases that are clinically relevant. The identification of these entities is based on a combination of morphology, immunophenotype, genetic and molecular features and clinical manifestations. The relevance of these criteria is variable in different entities but the diagnosis always requires a multidisciplinary approach. The classification constitutes a reference framework for clinical practice and for the investigation of these neoplasms in all perspectives. New advances in the immunological, genetic and molecular alterationsof these neoplasms have expanded our understanding refining the diagnostic criteria, identifying new clinical and biological subtypes and providing solid basis for the development of new therapeutic strategies. This chapter reviews the basis of the classification and the diagnostic criteria required in each entity and also incorporates relevant new information generated since the publication of the classification, particularly in the field of molecular and genetic alterations, that may contribute to the diagnosis and new therapeutic perspectives.

AB - The classification of lymphoid neoplasms of the World Health Organization (WHO) is based on two major principles: stratification of the neoplasms according to their cell lineage (B or T/NK) and the definition of non-overlapping distinct diseases that are clinically relevant. The identification of these entities is based on a combination of morphology, immunophenotype, genetic and molecular features and clinical manifestations. The relevance of these criteria is variable in different entities but the diagnosis always requires a multidisciplinary approach. The classification constitutes a reference framework for clinical practice and for the investigation of these neoplasms in all perspectives. New advances in the immunological, genetic and molecular alterationsof these neoplasms have expanded our understanding refining the diagnostic criteria, identifying new clinical and biological subtypes and providing solid basis for the development of new therapeutic strategies. This chapter reviews the basis of the classification and the diagnostic criteria required in each entity and also incorporates relevant new information generated since the publication of the classification, particularly in the field of molecular and genetic alterations, that may contribute to the diagnosis and new therapeutic perspectives.

KW - B-cell lymphoma

KW - Hodgkin lymphoma

KW - Lymphoid neoplasms

KW - T/NK-cell lymphoma

KW - WHO classification

UR - http://www.scopus.com/inward/record.url?scp=84976408123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976408123&partnerID=8YFLogxK

U2 - 10.1002/9781118853771.ch31

DO - 10.1002/9781118853771.ch31

M3 - Chapter

AN - SCOPUS:84976408123

SN - 9781118854327

SP - 575

EP - 600

BT - Postgraduate Haematology: Seventh Edition

PB - Wiley Blackwell

ER -