The clinical efficacy of oral levodopa methyl ester solution in reversing afternoon ''off'' periods in Parkinson's disease

M. J. Steiger, F. Stocchi, A. Carta, S. Ruggieri, A. Agnoli, N. P. Quinn, C. D. Marsden

Research output: Contribution to journalArticle

Abstract

We compared the efficacy of a single dose of an oral solution of levodopa methyl ester (ME) to that of standard levodopa, in the form of a single dose of Madopar, in reversing afternoon ''off'' periods in 12 patients with Parkinson's disease (PD). The highly soluble ME solution led to a significantly more rapid reversal of ''off'' periods. This preparation may therefore convey a clinical advantage in patients experiencing motor fluctuations whilst taking multiple daily dosages of levodopa, particularly in those with long or highly variable latency to the next ''on'' period.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalClinical Neuropharmacology
Volume14
Issue number3
Publication statusPublished - 1991

Fingerprint

Levodopa
Parkinson Disease
Esters
levodopa methyl ester
levodopa drug combination benserazide

Keywords

  • Levodopa methyl ester
  • Motor fluctuations
  • Parkinson's disease

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Steiger, M. J., Stocchi, F., Carta, A., Ruggieri, S., Agnoli, A., Quinn, N. P., & Marsden, C. D. (1991). The clinical efficacy of oral levodopa methyl ester solution in reversing afternoon ''off'' periods in Parkinson's disease. Clinical Neuropharmacology, 14(3), 241-244.

The clinical efficacy of oral levodopa methyl ester solution in reversing afternoon ''off'' periods in Parkinson's disease. / Steiger, M. J.; Stocchi, F.; Carta, A.; Ruggieri, S.; Agnoli, A.; Quinn, N. P.; Marsden, C. D.

In: Clinical Neuropharmacology, Vol. 14, No. 3, 1991, p. 241-244.

Research output: Contribution to journalArticle

Steiger, MJ, Stocchi, F, Carta, A, Ruggieri, S, Agnoli, A, Quinn, NP & Marsden, CD 1991, 'The clinical efficacy of oral levodopa methyl ester solution in reversing afternoon ''off'' periods in Parkinson's disease', Clinical Neuropharmacology, vol. 14, no. 3, pp. 241-244.
Steiger, M. J. ; Stocchi, F. ; Carta, A. ; Ruggieri, S. ; Agnoli, A. ; Quinn, N. P. ; Marsden, C. D. / The clinical efficacy of oral levodopa methyl ester solution in reversing afternoon ''off'' periods in Parkinson's disease. In: Clinical Neuropharmacology. 1991 ; Vol. 14, No. 3. pp. 241-244.
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