The clinical impact of a cardiologic follow-up in breast cancer survivors

an observational study.

G. Gallucci, M. Coccaro, G. Storto, L. Lapadula, A. Tartarone, A. Nappi, A. Cammarota, C. Buonerba, G. Di Lorenzo, V. Fusco, M. Aieta

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Anthracycline-containing chemotherapy (A-CHT) can induce late cardiotoxicity adding a considerable burden to cardiovascular risk. Irradiation of left breast cancer has also been associated to an increased risk of cardiovascular disease. The aim of this observational study is to prove the usefulness of an accurate cardiovascular evaluation in left breast cancer survivors treated with radiotherapy (RT) and A-CHT. Patients with left breast cancer, on follow-up after treatment with A-CHT plus RT in an adjuvant setting, were eligible for this observational study. Patients underwent cardiovascular assessment with myocardial perfusion imaging. Thirty patients were enrolled in the study: mean age at diagnosis 55.8 years; stage: I/III; Er and/or pgR status: positive in 24/30 pts; 3 patients in pre-menopausal status. Twenty-two patients (73.3 percent) had normal perfusion imaging, 1 patient (3.3 percent) had a fixed myocardial perfusion defect, 7 patients (23.3 percent) had reversible myocardial perfusion defects; 1 patient (3 percent) with normal perfusion scan showed depressed rest and stress LVEF. Only 1 patient had a large defect and underwent coronary angiography and percutaneous coronary intervention. Five patients with small defect showed normal coronary arteries at Multislice Computed Tomography. Cardiovascular followup may reveal signs of A-CHT or RT-induced cardiotoxicity. A stress test combined with MPI- and GATED-derived data of ventricular systolic performance after stress can give information on the coronary reserve and the contractile reserve and allow early appropriate treatment.

Original languageEnglish
Pages (from-to)1221-1227
Number of pages7
JournalInternational Journal of Immunopathology and Pharmacology
Volume23
Issue number4
Publication statusPublished - Oct 2010

Fingerprint

Observational Studies
Survivors
Breast Neoplasms
Anthracyclines
Drug Therapy
Perfusion
Radiotherapy
Adjuvant Radiotherapy
Myocardial Perfusion Imaging
Perfusion Imaging
Multidetector Computed Tomography
Percutaneous Coronary Intervention
Coronary Angiography
Exercise Test
Coronary Vessels
Cardiovascular Diseases
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Cite this

The clinical impact of a cardiologic follow-up in breast cancer survivors : an observational study. / Gallucci, G.; Coccaro, M.; Storto, G.; Lapadula, L.; Tartarone, A.; Nappi, A.; Cammarota, A.; Buonerba, C.; Di Lorenzo, G.; Fusco, V.; Aieta, M.

In: International Journal of Immunopathology and Pharmacology, Vol. 23, No. 4, 10.2010, p. 1221-1227.

Research output: Contribution to journalArticle

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