TY - JOUR
T1 - The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease
T2 - case reports and a review of the literature
AU - Infantino, M.
AU - Meacci, F.
AU - Grossi, V.
AU - Manfredi, M.
AU - Li Gobbi, F.
AU - Sarzi-Puttini, P.
AU - Atzeni, F.
AU - Benucci, M.
PY - 2017/2
Y1 - 2017/2
N2 - Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD. We described two patients ANA and anti-DFS70 positive in which the use of new method allowing the immunoadsorption of anti-DFS70 antibodies has permitted to exclude the incorrect diagnosis of CTD.
AB - Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD. We described two patients ANA and anti-DFS70 positive in which the use of new method allowing the immunoadsorption of anti-DFS70 antibodies has permitted to exclude the incorrect diagnosis of CTD.
KW - Anti-DFS70 antibodies
KW - Anti-nuclear antibodies
KW - Undifferentiated connective tissue disease
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U2 - 10.1007/s12026-016-8836-4
DO - 10.1007/s12026-016-8836-4
M3 - Article
AN - SCOPUS:84978544536
VL - 65
SP - 293
EP - 295
JO - Immunologic Research
JF - Immunologic Research
SN - 0257-277X
IS - 1
ER -