The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature

M. Infantino, F. Meacci, V. Grossi, M. Manfredi, F. Li Gobbi, P. Sarzi-Puttini, F. Atzeni, M. Benucci

Research output: Contribution to journalArticlepeer-review

Abstract

Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD. We described two patients ANA and anti-DFS70 positive in which the use of new method allowing the immunoadsorption of anti-DFS70 antibodies has permitted to exclude the incorrect diagnosis of CTD.

Original languageEnglish
Pages (from-to)293-295
Number of pages3
JournalImmunologic Research
Volume65
Issue number1
DOIs
Publication statusPublished - Feb 2017

Keywords

  • Anti-DFS70 antibodies
  • Anti-nuclear antibodies
  • Undifferentiated connective tissue disease

ASJC Scopus subject areas

  • Immunology

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