The clinical impact of chronic transplant glomerulopathy in cyclosporine era

Giovanni Banfi, Margarita Villa, Donata Cresseri, Claudio Ponticelli

Research output: Contribution to journalArticle

Abstract

Background. The clinical impact of chronic transplant glomerulopathy (CTG) on the outcome of kidney allograft receiving calcineurin inhibitors (CNIs) remains uncertain. A retrospective study of renal transplant recipients at Ospedale Maggiore of Milan was undertaken to evaluate the clinical outcome of patients with CTG. Methods. Among 666 biopsies taken at least 6 months after transplantation (Tx) in 498 transplant patients treated with CNIs, 28 cases (5.6%) of chronic transplant glomerulopathy (CTG) were identified and their clinical features at Tx, at follow-up and graft survival were compared with those of 56 controls transplanted in the same period and with kidney functioning 12 months after Tx. Clinical characteristics at biopsy and at 1 year after Tx were similar in the two groups. Results. After diagnosis graft function deteriorated in 22 patients (78.5%), while it remained stable in 6. Graft loss developed in 92 % of patients with proteinuria >2.5 g/day and in 33 % of those with lower proteinuria (P

Original languageEnglish
Pages (from-to)1392-1397
Number of pages6
JournalTransplantation
Volume80
Issue number10
DOIs
Publication statusPublished - Nov 2005

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Keywords

  • Chronic transplant glomerulopathy
  • Cyclosporine
  • Kidney transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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